Landmark Trials in Endocrinology & Metabolism
Practice-changing trialsPractice-changing landmark trials in endocrinology and metabolism, organized for rapid clinical review, exam preparation, teaching, and evidence-based patient care.
Letrozole vs Programmed FET in PCOS: No Difference in Pregnancy Rates
A small open-label RCT found no significant difference in clinical pregnancy rates between letrozole ovulation and programmed endometrial preparation for frozen embryo transfer in women with PCOS, with letrozole needing simpler luteal support. PICO summary and expert commentary.
CGM-Guided Individualised Care in Diabetic Pregnancy: A Small RCT
A small single-centre RCT of CGM-guided individualised care versus self-monitoring in 80 women with diabetes in pregnancy, with no between-group glycaemic superiority demonstrated. PICO summary and expert commentary.
Does Weight Loss Affect Vitamin D Levels Differently in Women and Men?
A secondary analysis of a weight-loss-maintenance RCT found that low-calorie-diet weight loss raised serum 25(OH)D in both sexes, but further loss and low baseline vitamin D tracked with maintenance only in women. PICO summary and expert commentary.
Does a Low-Glycemic Carbohydrate Product Improve Maternal Glycemia in Obese Pregnant Women?
A manufacturer-sponsored randomized trial of a low-glycemic-index/slow-digesting carbohydrate product in obese pregnant women found no effect on the primary glycemic outcomes. PICO summary and expert commentary.
Can Moxibustion Plus Low-Dose Tadalafil Improve Erectile Dysfunction in Diabetic Patients?
A three-arm RCT finds moxibustion plus low-dose tadalafil outperforms either alone for diabetic erectile dysfunction, in an unblinded single-centre setting. PICO summary and commentary.
Wuziyuye Decoction Improves Sperm Parameters in Diabetic Asthenospermia: Chinese RCT
An RCT finds Wuziyuye Decoction improves sperm motility and concentration over L-carnitine in diabetic men, but without improving pregnancy rates. PICO summary and commentary.