Practice-changing landmark trials in endocrinology and metabolism, organized for rapid clinical review, exam preparation, teaching, and evidence-based patient care.
A secondary analysis of the Minnesota Green Tea Trial finds high-dose green tea extract does not reduce inflammatory markers in overweight postmenopausal women, a robust null result. PICO summary and commentary.
A 24-week RCT finds neither a low-carbohydrate nor a Mediterranean diet significantly changes bone turnover markers in young people with type 1 diabetes, an exploratory null result. PICO summary and commentary.
An open-label RCT finds combining metformin and liraglutide reduces weight, visceral fat, and free testosterone more than metformin alone in PCOS, with a rat study suggesting a gut-microbiota mechanism. PICO summary and commentary.
A prospective RCT finds an improved ultrasound-guided RFA protocol with hydrodissection achieves higher clinical success and far less recurrent laryngeal nerve injury in secondary hyperparathyroidism. PICO summary and commentary.
A small crossover study finds high- and moderate-intensity interval exercise equally reduce post-meal triglycerides in postmenopausal women, with moderate intensity better tolerated. PICO summary and commentary.
A small RCT finds preoperative calcium and magnesium before thyroidectomy yields numerically lower hypocalcaemia and earlier recovery in Graves' patients, but the differences were not significant. PICO summary and commentary.
A 52-week phase III RCT finds sitagliptin preserves hip bone density in women with type 2 diabetes, which declines on placebo, but with no effect at other sites. PICO summary and commentary.
A combined mouse and clinical study finds the anabolic agent rhPTH(1-34) reverses low bone turnover in type 2 diabetic bone disease and improves bone density more than alendronate. PICO summary and commentary.
A double-blind RCT finds a single high dose of vitamin D before an ultramarathon favourably shifts bone turnover markers, though mega-dosing remains experimental. PICO summary and commentary.
A 12-month study finds adolescents with poorly controlled type 1 diabetes have low bone density, but glycaemic change does not correlate with bone, while IGF-1 does. PICO summary and commentary.
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