Summary: In 70 Iranian women with newly diagnosed PCOS (aged 15–40 years), 330 mg of Salvia officinalis extract daily for…
Browsing: Landmark Trials in Endocrinology & Metabolism
Practice-changing landmark trials in endocrinology and metabolism, organized for rapid clinical review, exam preparation, teaching, and evidence-based patient care.
A 24-week double-blind feasibility trial (n=12) found LT4 monotherapy did not normalize free T4 and total T3 after thyroidectomy while LT4-LT3 did, but weight and cholesterol differences were non-significant. PICO summary and expert commentary.
The phase 3 PaTHway trial finds TransCon PTH frees most adults with hypoparathyroidism from conventional therapy and halves urinary calcium. PICO summary and expert commentary.
A phase 3 trial finds recombinant human TSH non-inferior to thyroid hormone withdrawal for radioiodine ablation in intermediate-risk thyroid cancer, with fewer adverse events. PICO summary and commentary.
An open-label phase 3 noninferiority trial finds recombinant human thyrotropin matches thyroid hormone withdrawal for radioactive iodine ablation success in intermediate-risk differentiated thyroid cancer, with fewer adverse events. PICO summary and expert commentary.
Pooled RCTs find mild sleep restriction lowers TSH in women specifically, with no effect overall and no change in FT4. PICO summary and expert commentary.