Browsing: Type 2 Diabetes

A four-arm trial finds combination aerobic-resistance exercise is the only programme to improve objective sleep in type 2 diabetes, alongside abdominal fat loss. PICO summary and commentary.

A crossover trial finds almond milk offers no glycaemic advantage over carbohydrate-matched cow milk in type 2 diabetes. PICO summary and expert commentary.

A small 52-week single-centre randomised trial found once-weekly semaglutide shifted lipoprotein subfractions toward a less atherogenic profile versus sitagliptin in type 2 diabetes. PICO summary and expert commentary.

A single-centre randomised trial testing team-delivered multifactorial care against standard care in type 2 diabetes, with modest gains in HbA1c, eGFR and blood pressure control. PICO summary and expert commentary.

Clinical Context SGLT2 inhibitors like canagliflozin are cornerstone medications for type 2 diabetes, providing glycemic control alongside cardiovascular and renal…

A double-blind randomised trial of dapagliflozin versus placebo for myocardial fibrosis on cardiac MRI in 100 patients with type 2 diabetes and HFpEF. PICO summary and expert commentary.

A small mechanistic study finds exenatide plus glucagon doubles myocardial glucose uptake in type 2 diabetes, a proof-of-concept for cardiac metabolic effects. PICO summary and commentary.

An RCT finds the GLP-1 analogue Ebenatide improves glycaemia, time in range, and body composition in type 2 diabetes, confirming a class effect. PICO summary and commentary.

A small single-centre RCT testing CGM-guided individualised care versus self-monitored blood glucose in 80 pregnant women with diabetes. PICO summary and expert commentary.

An acute crossover infusion study (n=8) found exenatide-glucagon co-infusion raised myocardial glucose uptake and a diastolic strain rate marker in type 2 diabetes. PICO summary and expert commentary.