Clinical evidence summaries for type 2 diabetes, including glycaemic therapies, cardiovascular outcomes, kidney protection, complications, technology, obesity, and long-term safety.
An exploratory secondary analysis of two Phase 2 trials reports that oral orforglipron lowered blood pressure, LDL cholesterol, triglycerides, ApoB, ApoC3, and hsCRP versus placebo, though no cardiovascular events were measured. PICO summary and expert commentary.
A nested qualitative process evaluation of the SuMMiT-D SMS intervention found patients described holistic, context-dependent benefits rather than measured adherence gains. PICO summary and expert commentary.
A secondary analysis of a Swedish RCT links higher engagement with a smartphone dietary-education app to modest dietary improvements, with no significant cardiometabolic marker changes, in adults with type 2 diabetes. PICO summary and expert commentary.
A multicentre open-label RCT testing whether 12-month mHealth home telemonitoring improves blood pressure and HbA1c versus standard care in older adults with hypertension and type 2 diabetes. PICO summary and expert commentary.
A 58-patient single-site implementation RCT of the community-health-worker-led TIME programme for uninsured Hispanic adults with type 2 diabetes, with PICO summary and expert commentary.
An open-label randomized trial in newly diagnosed type 2 diabetes found acarbose and vildagliptin both lowered plasma TMAO, with a greater fall on acarbose. PICO summary and expert commentary.
An MRI sub-study of the MemAID trial found that 24 weeks of intranasal insulin increased several hippocampal and medio-prefrontal resting-state connectivity measures versus placebo in 11 adults with type 2 diabetes. PICO summary and expert commentary.
A pragmatic RCT testing whether brief telehealth problem-solving therapy (LISTEN) reduces diabetes distress in adults with type 1 and type 2 diabetes versus usual web-based resources. PICO summary and expert commentary.
A 602-participant Taiwanese RCT found a single one-hour diabetes Conversation Map session modestly lowered three-month HbA1c, with the benefit mediated by diet rather than exercise. PICO summary and expert commentary.
A Peplau-theory self-care education programme improved self-reported self-care but not total treatment adherence in 102 elderly patients with diabetes. PICO summary and expert commentary.
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