A small randomized three-arm trial comparing empagliflozin, sitagliptin, and metformin on glycemic and cardio-metabolic parameters in type 2 diabetes, with significance shown mainly against the metformin arm. PICO summary and expert commentary.
Browsing: Type 2 Diabetes
Landmark trials and recent evidence on type 2 diabetes management, glucose-lowering therapy, and outcomes.
A post-hoc ACCORD-BP analysis links intensive blood pressure control to lower cardiovascular events in diabetics with prior stroke, without raising recurrent stroke. PICO summary and commentary.
An RCT finds the Diabetes Conversation Map improves knowledge, self-management, and self-efficacy in type 2 diabetes, though without clinical endpoints. PICO summary and commentary.
A triple-blind RCT finds cinnamon supplementation does not significantly reduce weight or BMI in type 2 diabetes. PICO summary and expert commentary.
A small RCT finds hyaluronic acid adds no periodontal benefit over mechanical cleaning in diabetic periodontitis, though HbA1c fell only in the HA group. PICO summary and commentary.
A four-arm trial finds combination aerobic-resistance exercise is the only programme to improve objective sleep in type 2 diabetes, alongside abdominal fat loss. PICO summary and commentary.
A crossover trial finds almond milk offers no glycaemic advantage over carbohydrate-matched cow milk in type 2 diabetes. PICO summary and expert commentary.
A small 52-week single-centre randomised trial found once-weekly semaglutide shifted lipoprotein subfractions toward a less atherogenic profile versus sitagliptin in type 2 diabetes. PICO summary and expert commentary.
A single-centre randomised trial testing team-delivered multifactorial care against standard care in type 2 diabetes, with modest gains in HbA1c, eGFR and blood pressure control. PICO summary and expert commentary.
Clinical Context SGLT2 inhibitors like canagliflozin are cornerstone medications for type 2 diabetes, providing glycemic control alongside cardiovascular and renal…