A mechanistic randomized trial found empagliflozin reduced total-body norepinephrine turnover at 1 day and 12 weeks even as hepatic glucose production rose, with the two changes inversely correlated. PICO summary and expert commentary.
Browsing: Diabetes
Evidence summaries and landmark trials across type 1, type 2, prevention, glycaemic control, complications, and diabetes technology.
Summary: In type 2 diabetic stage-II periodontitis patients, non-surgical periodontal therapy with adjunctive hyaluronic acid (HA) gel significantly improved periodontal…
“`html Summary: In patients with type 2 diabetes mellitus, a combined exercise program significantly reduced abdominal fat and improved sleep…
A small crossover trial found almond milk offered no postprandial glycaemic benefit over 2% cow milk in adults with type 2 diabetes, with the primary glucose endpoint null. PICO summary and expert commentary.
A small pilot finds curcumin lowers HbA1c in prediabetic older adults, but without changing weight, lipids, or overall gut microbiome diversity. PICO summary and commentary.
A 52-week trial finds semaglutide shifts lipoprotein subfractions toward a less atherogenic profile in type 2 diabetes, independent of weight or glucose change. PICO summary and commentary.
Summary: In patients with diabetic erectile dysfunction (ED), high-activity placenta-derived mesenchymal stem cells (hPMSCs) combined with low-intensity extracorporeal shock wave…
A double-blinded RCT in 162 adults found wound blotting-guided biofilm management improved the DMIST wound score and biofilm removal over three weeks in diabetic foot ulcers, though only surrogate endpoints were measured. PICO summary and expert commentary.
A single-centre randomised controlled trial testing multidisciplinary multifactorial care against standard care in 192 adults with type 2 diabetes, with a modest HbA1c reduction and improved eGFR. PICO summary and expert commentary.
A MEAD post-hoc analysis finds the dexamethasone implant doubles diabetic macular oedema resolution, with thicker baseline maculae resolving more slowly. PICO summary and commentary.