Does Curcumin Help with Blood Sugar and Gut Health in Prediabetic Seniors?
A small pilot finds curcumin lowers HbA1c in prediabetic older adults, but without changing weight, lipids, or overall gut microbiome diversity. PICO summary and commentary.
Diabetes
Evidence summaries and landmark trials across type 1, type 2, prevention, glycaemic control, complications, and diabetes technology.
Does Semaglutide Improve Lipid Profiles in Type 2 Diabetes?
A 52-week trial finds semaglutide shifts lipoprotein subfractions toward a less atherogenic profile in type 2 diabetes, independent of weight or glucose change. PICO summary and commentary.
Does Biofilm-Guided Wound Care Improve Diabetic Foot Ulcers?
A double-blinded RCT in 162 adults found wound blotting-guided biofilm management improved the DMIST wound score and biofilm removal over three weeks in diabetic foot ulcers, though only surrogate endpoints were measured. PICO summary and expert commentary.
Multifactorial Care in Type 2 Diabetes: A Single-Centre RCT
A single-centre randomised controlled trial testing multidisciplinary multifactorial care against standard care in 192 adults with type 2 diabetes, with a modest HbA1c reduction and improved eGFR. PICO summary and expert commentary.
What Factors Affect DME Resolution After Dexamethasone Treatment?
A MEAD post-hoc analysis finds the dexamethasone implant doubles diabetic macular oedema resolution, with thicker baseline maculae resolving more slowly. PICO summary and commentary.
Does Dapagliflozin Plus Exenatide Improve Beta-Cell Function More Than Either Alone?
A phase IV randomized trial in 90 adults with type 2 diabetes found dapagliflozin plus exenatide augmented beta-cell function and insulin sensitivity above either agent alone, on surrogate OGTT measures. PICO summary and expert commentary.
Does Orange Juice Spike Blood Sugar at Breakfast in Type 2 Diabetes?
A crossover trial finds orange juice with breakfast raises glucose no more than whole orange or a sugary drink of matched sugar in well-controlled type 2 diabetes. PICO summary and commentary.
Can a New Fat and Glucose Index Predict Heart Risks in Type 2 Diabetes?
An ACCORD analysis finds a triglyceride-glucose-waist index independently predicts cardiovascular events and mortality in type 2 diabetes, beating TyG alone. PICO summary and commentary.
Can Community Programs Improve Diabetes and Oral Health?
A four-arm community trial finds integrated diabetes-and-periodontitis self-management improves glycaemic control and oral health more than single-disease care. PICO summary and commentary.