An RCT finds intraoperative dexmedetomidine reduces glucose variability, insulin requirements, and CRP in diabetic off-pump CABG patients, though endpoints are surrogate. PICO summary and commentary.
Browsing: Diabetes
Evidence summaries and landmark trials across type 1, type 2, prevention, glycaemic control, complications, and diabetes technology.
A phase 2 RCT finds placenta-derived cell therapy (PDA-002) for diabetic foot ulcers works best at the lowest dose and in the peripheral-artery-disease subgroup, a dose- and subgroup-specific signal. PICO summary and commentary.
A crossover RCT finds weekly structured telehealth modestly lowers HbA1c and improves time in range in poorly controlled paediatric type 1 diabetes, without more hypoglycaemia. PICO summary and commentary.
Summary: In adults with persistent and recalcitrant diabetic foot ulcers that failed to heal with conventional treatment, full-thickness decellularized placental…
A pragmatic cluster RCT finds an SMS lifestyle intervention for prediabetes does not improve HbA1c versus usual care, illustrating that engagement does not equal efficacy. PICO summary and commentary.
Clinical Context Pediatric type 1 diabetes management is notoriously difficult, with most children and adolescents failing to achieve glycemic targets.…
An RCT finds family-centred foot-care training improves knowledge, practice, and support in diabetes, with no ulcers in the intervention group versus 8% control. PICO summary and commentary.
Clinical Context Diabetic foot ulcers (DFUs) represent one of the most devastating and preventable complications of diabetes. In India, where…
Clinical Context Diabetic peripheral neuropathy affects up to 50% of patients with diabetes, and painful diabetic neuropathy (PDN) develops in…
A secondary analysis finds diabetes app users still average only 17 g/day fibre over a year, below target, with no link to HbA1c, suggesting basic app feedback is not enough. PICO summary and commentary.