Summary: In older adults with type 2 diabetes, an interactive virtual assistant device programmed with a behavioral intervention significantly improved mental distress, quality of life, diabetes self-care behaviors, and glycemic control compared to usual care without the device, though it was associated with no adverse events or withdrawals. PICO Description Population Older adults (≥65 years) diagnosed with type 2 diabetes receiving care at an academic medical center in Brazil. Intervention Use of an interactive virtual assistant device (Amazon Echo Dot, 3rd generation) programmed with a behavioral intervention model over a 12-week period. Comparison Standard diabetes care alone without the addition…
Author: FWA
Summary: In individuals with type 2 diabetes (T2D), combined treatment with Empagliflozin and Linagliptin significantly improved glycemic control and restored a healthy urinary microbiota compared to Empagliflozin alone or healthy controls, though it was associated with fewer incidences of urinary dysbiosis and potential infection-related side effects. PICO Description Population Adults with type 2 diabetes (T2D); 30 participants recruited for a 12-week open-label randomized study. Fifteen additional healthy individuals served as baseline controls. Intervention Combined therapy of Empagliflozin and Linagliptin administered over a 12-week period with evaluation of clinical markers and urinary microbiota via RT-qPCR and 16S rRNA sequencing. Comparison Empagliflozin…
Summary: In patients with proliferative diabetic retinopathy (PDR) complicated by non-resolving vitreous hemorrhage and tractional retinal detachment, pars plana vitrectomy (PPV) with internal limiting membrane (ILM) peeling significantly reduced the incidence of epiretinal membrane (ERM) formation and decreased the need for repeat anti-VEGF injections compared to PPV without ILM peeling, though it was associated with no significant changes in visual acuity or central macular thickness. PICO Description Population Patients (n = 57) with proliferative diabetic retinopathy (PDR) presenting non-clearing vitreous hemorrhage and tractional retinal detachment. Intervention Pars plana vitrectomy (PPV) with internal limiting membrane (ILM) peeling (n = 26). Comparison…
Summary: In adults with type 2 diabetes, various glucose-lowering medications as studied in the GRADE trial showed small differences in medication adherence and unclear clinical impact on glycemic control compared to other treatment groups within the comparative effectiveness study, though lower adherence was strongly associated with worsening glycemic control. PICO Description Population Adults with type 2 diabetes enrolled in the GRADE study, receiving glucose-lowering therapies. Intervention Four distinct glucose-lowering treatments as part of the GRADE comparative effectiveness trial. Comparison Other glucose-lowering treatments evaluated within the GRADE study arms. Outcome Adherence was generally high across treatment groups with minimal differences; however,…
Summary: In adults with type 2 diabetes of less than 10 years’ duration inadequately controlled on metformin monotherapy, the addition of insulin glargine, glimepiride, liraglutide, or sitagliptin significantly maintained high medication adherence and improved glycemic outcomes across all groups compared to each other, with minor differences observed at year 3 favoring glimepiride and sitagliptin over liraglutide, though it was associated with clinically insignificant variations in adherence between groups. PICO Description Population Adults with type 2 diabetes (duration <10 years), HbA1c 6.8%-8.5%, treated with metformin monotherapy. Intervention Addition of second-line agents: insulin glargine, glimepiride, liraglutide, or sitagliptin; adherence measured over 3…
Summary: In older patients with coronary heart disease (CHD) and type 2 diabetes (T2DM), home-based telemedicine-supported exercise training focusing on longer exercise duration significantly improved maximal oxygen uptake (V̇O₂peak) compared to less exercise duration or varying intensity levels, though it was associated with no notable adverse effects but required early engagement for sustained adherence. PICO Description Population Older adults (mean age 67.9 years, 84.1% men) with both coronary heart disease (CHD) and type 2 diabetes mellitus (T2DM), participating in the LeIKD trial. Intervention Home-based, telemedicine-supported endurance exercise training over six months, with variable intensity and increasing weekly exercise duration. Comparison…
Summary: In patients with diabetes and coronary artery disease undergoing percutaneous coronary intervention (PCI), the Abluminus DES+ sirolimus-eluting stent (SES) significantly improved clinical outcomes including reduced restenosis rates and comparable safety profiles compared to the XIENCE durable-polymer everolimus-eluting stent (EES), though it was associated with similar rates of adverse cardiovascular events and stent thrombosis. PICO Description Population Patients with diabetes mellitus and coronary artery disease undergoing percutaneous coronary intervention. Intervention Abluminus DES+ sirolimus-eluting stent (thin-strut cobalt-chromium stent with abluminal and balloon-surface sirolimus coating). Comparison XIENCE durable-polymer everolimus-eluting stent (EES), a widely-used polymer-based everolimus-eluting stent. Outcome Abluminus DES+ SES demonstrated significantly…
Summary: In diabetes-free individuals with obesity and metabolic dysfunction-associated steatotic liver disease (MASLD), berberine treatment at a dose of 1 g/day for 6 months did not significantly reduce visceral adipose tissue (VAT) area or liver fat content compared to placebo, though it was associated with improvements in lipid and inflammatory markers and had a similar rate of adverse events to placebo. PICO Description Population Diabetes-free adults with obesity and metabolic dysfunction-associated steatotic liver disease (MASLD), enrolled at 11 hospitals in China. Intervention Oral berberine at a daily dose of 1 gram for 6 months. Comparison Matching placebo administered orally once…
Summary: In obese men, intranasal vitamin C application (80 mg/day for 8 days) significantly improved insulin sensitivity, increased serum vitamin C levels, and attenuated neuroenergetic phosphocreatine (PCr) decline compared to placebo treatment, though it was associated with no reported adverse effects. PICO Description Population Fifteen obese men (BMI >30 kg/m2) and fifteen normal weight men (BMI 20–25 kg/m2). Intervention Intranasal administration of vitamin C (80 mg ascorbic acid/day) for 8 consecutive days. Comparison Placebo administered intranasally under the same protocol. Outcome In obese participants, vitamin C improved insulin sensitivity acutely (p = 0.003), increased serum vitamin C concentrations (p =…
Summary: In older Spanish adults with overweight/obesity and metabolic syndrome, a Mediterranean Diet and lifestyle intervention significantly improved perceived vitality, physical and mental well-being, and nutritional self-efficacy compared to usual behaviours lacking structured dietary or lifestyle intervention, though it was associated with barriers including low motivation, disease burden, mobility issues, and limited social support. PICO Description Population Spanish adults aged 60–81 years with overweight or obesity and diagnosed with metabolic syndrome participating in a randomized clinical trial. Intervention Mediterranean Diet and healthy lifestyle behavioural intervention supported by continuous contact with researchers, peer support, and nutritional education. Comparison Usual lifestyle practices…