Hormone Insight Editorial Team
Clinical archive
Extracorporeal Shockwave Therapy for Diabetic Foot Ulcers: A Feasibility Pilot
A feasibility pilot finds a definitive trial of shockwave therapy for diabetic foot ulcers is deliverable, with only a descriptive (not powered) trend toward faster healing at the higher dose. PICO summary and commentary.
Low-Power Laser and Ultrasound for Diabetic Polyneuropathy: Quality-of-Life Gains, Uncertain Pain Benefit
An RCT finds low-power laser therapy improves quality-of-life problem scores in diabetic polyneuropathy, but the neuropathy-severity difference between groups was not significant. PICO summary and commentary.
Cyperus rotundus Extract with Piperine for Weight Loss: Double-Blind Placebo-Controlled Trial
A 90-day manufacturer-funded RCT finds Cyperus rotundus extract with piperine, added to diet and exercise, reduces weight and central adiposity and improves lipids in obese adults. PICO summary and commentary.
Can a Nutritionist-Guided Video Help Pregnant Women Follow the Mediterranean Diet and Lower Gestational Diabetes Risk?
A large RCT finds a nutritionist-designed Mediterranean diet video improves adherence and reduces gestational diabetes from 25.1% to 20.7%, with fewer adverse outcomes. PICO summary and commentary.
Yoga for Glycemic Control in Low-Income Women with Type 2 Diabetes: RCT Results
A 12-week RCT finds structured yoga improves fasting glucose, HbA1c, and self-care in low-income women with type 2 diabetes, though the glycaemic effect exceeds typical yoga trials. PICO summary and commentary.
De-Escalation from Ticagrelor to Clopidogrel After MI in Diabetic Patients: Clinical Outcomes
A TALOS-AMI post hoc analysis finds switching from ticagrelor to clopidogrel a month after MI is consistent across diabetes status, though within-diabetes bleeding and ischemic differences were not significant. PICO summary and commentary.
How Does Empagliflozin Affect Heart Failure in Type 2 Diabetes Patients?
A small biomarker RCT finds empagliflozin reduces the renal tubular marker KIM-1 in diabetic heart failure with preserved ejection fraction, with no effect on other biomarkers. PICO summary and commentary.
Metformin Does Not Improve Insulin Resistance in Type 1 Diabetes: A Negative Trial
A 26-week double-blind RCT finds metformin does not reduce insulin resistance in adults with type 1 diabetes, with no change in endogenous glucose production versus placebo. PICO summary and commentary.
Can tibial nerve techniques enhance pain management for diabetic neuropathy?
A sham-controlled trial finds adding tibial nerve neurodynamic techniques to standard care reduces neuropathy severity and improves quality of life in diabetic neuropathy, though nerve conduction is unchanged. PICO summary and commentary.