A GRADE substudy finds adults adding a second drug to metformin maintain high medication adherence over 3 years with small between-drug differences, while lower adherence robustly predicts worse glycaemic control. PICO summary and commentary.
A secondary analysis of the LeIKD trial finds longer endurance-exercise duration, more than intensity, improves fitness in older patients with coronary heart disease and type 2 diabetes, with early engagement predicting adherence. PICO summary and commentary.
The ABILITY Diabetes Global trial finds the Abluminus DES+ stent fails non-inferiority to the XIENCE everolimus-eluting stent in diabetes, with higher repeat revascularisation and target-lesion failure. PICO summary and commentary.
A multicentre RCT finds berberine 1 g/day for 6 months does not reduce visceral or liver fat in obesity with fatty liver disease, though it modestly lowers LDL, apoB, and hs-CRP. PICO summary and commentary.
A small pilot finds 8 days of intranasal vitamin C improves insulin sensitivity and attenuates a brain phosphocreatine decline in men with obesity, without changing food intake. PICO summary and commentary.
A qualitative study finds older adults with metabolic syndrome adhere better to a Mediterranean diet with sustained professional support and family engagement, while limited partner support is a key barrier. PICO summary and commentary.
An RCT finds adding oral agents to short-term intensive insulin improves early glucose control and beta-cell measures in new type 2 diabetes, but does not improve 12-month remission rates. PICO summary and commentary.
A secondary analysis of the Minnesota Green Tea Trial finds high-dose green tea extract does not reduce inflammatory markers in overweight postmenopausal women, a robust null result. PICO summary and commentary.
A 12-week dose-response trial finds purified anthocyanin supplements up to 640 mg/day do not improve arterial stiffness, blood pressure, or cardiovascular risk in older adults with high blood sugar. PICO summary and commentary.
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