Author: FWA

Summary: In patients with type 2 diabetes mellitus having baseline HbA1c less than 7.5% (well-controlled diabetes), administration of AntiAGE-Biom probiotic targeting advanced glycation end product pathways demonstrated significant improvements in metabolic control and body composition metrics compared to placebo or standard care without probiotic supplementation, with no significant adverse events reported. PICO Description Population Patients with type 2 diabetes mellitus having baseline HbA1c less than 7.5% (well-controlled diabetes). Intervention Administration of AntiAGE-Biom probiotic, a formulation designed to target advanced glycation end product (AGE) pathways through specific bacterial strains. Comparison Placebo or standard care without probiotic supplementation. Outcome Significant improvements in…

Summary: In overweight/obese adults diagnosed with prediabetes, concurrent aerobic and resistance training combined with daily supplementation of microencapsulated persimmon-karonda polyphenols demonstrated significant improvements in glycemic markers including fasting glucose and HbA1c, along with decreased inflammatory biomarkers compared to concurrent training with placebo supplementation, with mild gastrointestinal side effects but no serious adverse events. PICO Description Population Overweight/obese adults diagnosed with prediabetes, characterized by impaired glucose metabolism but not meeting criteria for diabetes. Intervention Concurrent aerobic and resistance training combined with daily supplementation of microencapsulated persimmon-karonda polyphenols. Comparison Concurrent training with placebo supplementation administered under identical conditions. Outcome Significant improvements in…

Summary: In overweight prediabetic individuals, mulberry leaf and corn silk extracts delivered in a GOS milk matrix significantly inhibited α-amylase and α-glucosidase activity in vitro and attenuated postprandial glucose excursions compared to placebo/control, though it was associated with no significant adverse side effects reported. PICO Description Population Overweight individuals diagnosed with prediabetes exhibiting impaired glucose tolerance. Intervention Administration of mulberry leaf and corn silk extracts incorporated in a galacto-oligosaccharide (GOS) milk matrix. Comparison Placebo or control treatment without active plant extracts in the same milk matrix. Outcome Significant inhibition of α-amylase and α-glucosidase enzymatic activities in vitro; attenuation of postprandial…

Summary: In people at risk of gestational diabetes mellitus (GDM), especially with overweight or obesity, a preconception lifestyle intervention initiated before and continued throughout pregnancy significantly improved neonatal body composition and birth outcomes compared to standard care without the lifestyle intervention, though it was associated with no reported significant adverse side effects. PICO Description Population People at risk of gestational diabetes mellitus (GDM), predominantly with overweight or obesity, enrolled prior to conception. Intervention Structured preconception lifestyle intervention focusing on diet and physical activity, initiated before conception and continued throughout pregnancy. Comparison Standard care without specific lifestyle intervention during preconception or…

Summary: In individuals with type 1 diabetes (T1D), a digital twin-enhanced decision support system (DSS) incorporating a simulation-assisted bolus calculator significantly improved time-in-range (TIR) glucose control compared to standard bolus calculators without digital twin simulation support, though it was associated with comparable rates of hypoglycemia and no major adverse events reported. PICO Description Population Adults with type 1 diabetes using multiple daily injections or sensor-augmented pumps. Intervention Digital twin-enhanced decision support system (STUDIA) featuring simulation-assisted bolus calculator. Comparison Standard bolus calculator without digital twin simulation support. Outcome The intervention group showed significant improvement in time-in-range glucose levels, indicating better glycemic…

Summary: In adults with infected diabetic foot ulcers requiring microbiological sampling, tissue sampling to identify causative pathogens through biopsy or debridement demonstrated no clear evidence of superior healing outcomes and was associated with higher costs and lower quality-adjusted life years (QALYs) compared to swab sampling as a less invasive alternative, with trial recruitment challenges during COVID-19 pandemic introducing uncertainty in findings. PICO Description Population Adults with infected diabetic foot ulcers requiring microbiological sampling for wound management. Intervention Tissue sampling of infected diabetic foot ulcers to identify causative pathogens through biopsy or debridement. Comparison Swab sampling of infected diabetic foot ulcers…

Summary: In adults diagnosed with type 2 diabetes mellitus (n=62), cognitive motor dual-task blindfold training (CMDBT) combined with moderate-intensity aerobic and resistance exercise for 12 weeks demonstrated significantly greater improvement in Montreal Cognitive Assessment scores (3.32 vs 0.94 points) exceeding the minimal clinically important difference compared to conventional exercise alone without CMDBT, with no reported adverse events. PICO Description Population Adults diagnosed with type 2 diabetes mellitus (T2DM); n=62 participants equally divided into two groups. Intervention Cognitive motor dual-task blindfold training (CMDBT) combined with moderate-intensity aerobic and resistance exercise; 3 sessions per week for 12 weeks. Comparison Conventional exercise only…

Summary: In community-dwelling adults with type 2 diabetes mellitus (n=120) stratified by clinical risk level, a three-tiered linkage management model within the General Practice Residency Training (GPRT) framework using telemedicine and multidisciplinary teams demonstrated significantly greater reductions in fasting glucose, postprandial glucose, and HbA1c at 3 and 6 months along with improved self-care behaviors compared to conventional diabetes care without coordinated multi-level intervention, with no reported adverse effects and greater benefits in medium/high-risk subgroups. PICO Description Population 120 adults with type 2 diabetes mellitus recruited from a Chinese GPRT-affiliated community health center, stratified by clinical risk level (low, medium, high).…

Summary: In adults diagnosed with type 2 diabetes mellitus experiencing cognitive decline or impairment, cognitive motor dual task blindfold training (CMDBT) combined with conventional physical exercises demonstrated significantly enhanced cognitive functions compared to cognitive motor dual task training (CMDT) alone or standard conventional therapy without dual task training, supporting its use in rehabilitation programs for T2DM patients. PICO Description Population Adults diagnosed with type 2 diabetes mellitus experiencing cognitive decline or impairment. Intervention Cognitive motor dual task blindfold training (CMDBT) combined with conventional physical exercises including aerobic and resistance training. Comparison Cognitive motor dual task training (CMDT) alone or standard…

Summary: In patients with and without diabetes who are at risk for cardiovascular and renal complications, long-acting calcium channel blockers aimed at reducing blood pressure variability demonstrated significant improvements in cardiovascular and renal outcomes, especially among patients with diabetes compared to other antihypertensive treatment strategies without targeted reduction of blood pressure variability, supporting incorporation of blood pressure variability into risk assessments. PICO Description Population Patients with and without diabetes who are at risk for cardiovascular and renal complications as studied in the Anglo-Scandinavian Cardiac Outcomes Trial. Intervention Use of long-acting calcium channel blockers (such as amlodipine) aimed at reducing blood…