An RCT finds driving pressure-guided ventilation improves oxygenation and cuts intraoperative hypoxia in bariatric surgery, on physiological endpoints. PICO summary and commentary.
A recruitment analysis finds men, Hispanics, and Spanish speakers underenrol at every step of a diabetes exercise trial despite active outreach. PICO summary and commentary.
A 20-week RCT finds empagliflozin improves nerve conduction velocity in diabetic neuropathy but not clinical exam scores, with glycaemic confounding. PICO summary and commentary.
A small unblinded trial finds Huayu Tongluo moxibustion improves cognition and insulin resistance in type 2 diabetes, with high placebo potential. PICO summary and commentary.
The INTE-COMM Lancet trial finds community-based care matches facility care for stable HIV, diabetes, and hypertension in sub-Saharan Africa. PICO summary and expert commentary.
A clamp-based RCT finds metformin does not reduce hepatic insulin resistance in type 1 diabetes, arguing against its use as an insulin-sensitiser. PICO summary and commentary.
A secondary analysis finds beetroot supplements improve fatty acid and oxidant markers in coronary artery disease, but only short-term surrogates. PICO summary and commentary.
The CREDENCE trial demonstrated that canagliflozin reduced the composite of end-stage kidney disease, doubling of serum creatinine, or renal or cardiovascular death by 30% in patients with type 2 diabetes and albuminuric chronic kidney disease, becoming the first dedicated renal outcomes trial to demonstrate that an SGLT2 inhibitor could substantially slow the progression of diabetic nephropathy.
An RCT finds exogenous ketone salts produce no body-composition advantage over placebo on a hypocaloric diet. PICO summary and expert commentary.
A sham-controlled trial finds tibial nerve neurodynamic techniques improve neuropathy severity and quality of life in diabetic neuropathy, without changing nerve conduction. PICO summary and commentary.
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