A proof-of-concept cluster randomised trial found the INTEGRATE-D implementation support intervention feasible and acceptable in primary care, with mixed effects on process and clinical outcomes. PICO summary and expert commentary.
Browsing: PICO
A prespecified secondary analysis of a 12-week randomised trial found time-restricted eating did not change sleep, mood, or quality of life versus usual care in adults with overweight or obesity. PICO summary and expert commentary.
A randomised waitlist-controlled trial of a 10-week whole-food plant-based community programme in a predominantly Maori cohort: weight fell by 3.3 kg versus control, but HbA1c, cholesterol and waist changes were not significant. PICO summary and expert commentary.
Clinical Context GLP-1 receptor agonists produce substantial weight loss, but the mechanisms underlying this effect have been debated. Is weight…
A small 12-week randomized controlled trial in male recreational athletes with type 2 diabetes found that only the combined diet plus exercise arm improved both glycemic and body-composition markers, with small effect sizes. PICO summary and expert commentary.
A secondary analysis of a gestational-diabetes RCT (122 dyads) found cord-blood lipids, but not maternal lipids after correction, were associated with children’s beta-cell function at age 9. PICO summary and expert commentary.
Clinical Context Heart failure with preserved ejection fraction (HFpEF) represents one of the most challenging conditions in cardiovascular medicine. Unlike…
A single-centre randomised trial testing home telemedicine with Health Belief Model education against conventional care for HbA1c in older adults with type 2 diabetes. PICO summary and expert commentary.
A 93-patient RCT found structured exercise after gastric bypass did not improve the primary 2-hour glucose endpoint but added modest weight and fat-mass loss. PICO summary and expert commentary.
A small randomised trial finding that weight loss reduced IL-1β and MASLD comparably with liraglutide or lifestyle, and that baseline IL-1β predicted the extent of MASLD improvement. PICO summary and expert commentary.