A double-blind randomised trial of dapagliflozin versus placebo for myocardial fibrosis on cardiac MRI in 100 patients with type 2 diabetes and HFpEF. PICO summary and expert commentary.
Browsing: PICO
A small mechanistic study finds exenatide plus glucagon doubles myocardial glucose uptake in type 2 diabetes, a proof-of-concept for cardiac metabolic effects. PICO summary and commentary.
An RCT finds the GLP-1 analogue Ebenatide improves glycaemia, time in range, and body composition in type 2 diabetes, confirming a class effect. PICO summary and commentary.
A small single-centre RCT testing CGM-guided individualised care versus self-monitored blood glucose in 80 pregnant women with diabetes. PICO summary and expert commentary.
An acute crossover infusion study (n=8) found exenatide-glucagon co-infusion raised myocardial glucose uptake and a diastolic strain rate marker in type 2 diabetes. PICO summary and expert commentary.
An open-label randomised trial testing pharmacist-led collaborative care against usual care on EQ-5D quality of life and HbA1c in 400 patients with diabetes. PICO summary and expert commentary.
A small single-blind RCT (n=60) found a family-centered empowerment program raised diabetes acceptance and self-management questionnaire scores versus usual care, with no glycaemic outcomes measured. PICO summary and expert commentary.
A small pilot randomised trial (n=30) testing whether an 8-week integrated intensive exercise protocol improves body composition, functional capacity and quality of life in young adults with obesity versus diet plus brisk walking. PICO summary and expert commentary.
A published BMJ Open study protocol for a planned randomised controlled trial of a COM-B-based exercise intervention in prefrail older adults with diabetes; no efficacy results are reported. PICO summary and expert commentary.
A manufacturer-sponsored secondary analysis and propensity-matched real-world dataset suggest the mySugr digital logbook is associated with better glycaemic control, strongest in those with high baseline HbA1c. PICO summary and expert commentary.