An RCT finds seated exercise gives greater pain relief, knee function, and physical quality of life than standing exercise in obese women with knee osteoarthritis, while standing favours mental quality of life. PICO summary and commentary.
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A combined clinical and mechanistic study finds a TCM formula (Suyin Detoxification Prescription) reduces creatinine and proteinuria in diabetic nephropathy via an FXR pathway, though clinical evidence remains preliminary. PICO summary and commentary.
A randomised trial finds a brief four-session online programme reduces diabetes stigma and improves body image and coping in adults with type 1 diabetes, sustained at follow-up. PICO summary and commentary.
A large international RCT finds automated insulin delivery (MiniMed 670G/770G) improves HbA1c in those above 8% and reduces hypoglycaemia in those at target versus multiple daily injections in type 1 diabetes. PICO summary and commentary.
A 6-month open-label RCT finds adding a Mediterranean diet and nutritional supplements to dapagliflozin improves glycaemia, albuminuria, nutrition, and quality of life more than dapagliflozin alone in diabetic nephropathy. PICO summary and commentary.
An RCT finds combining HIIT with asparagus root extract improves oxidative, inflammatory, and lipid markers in overweight young adults, while the extract alone raises a pro-oxidant marker. PICO summary and commentary.
An RCT finds adding a 2-3 week course of intravenous alprostadil to standard care improves the clinical response rate and lipids in diabetic foot or neuropathy, though the trial was unblinded. PICO summary and commentary.
A 24-week RCT finds Bluetooth-enabled glucometers do not improve glucose control over traditional glucometers in telehealth insulin titration, though they reduce emergency department visits. PICO summary and commentary.
A 24-week RCT finds neither a low-carbohydrate nor a Mediterranean diet significantly changes bone turnover markers in young people with type 1 diabetes, an exploratory null result. PICO summary and commentary.
Summary: In pregnant women with gestational diabetes mellitus (GDM), real-time continuous glucose monitoring (CGM) did not improve the primary composite…