In a two-center randomized trial, diabetes-team CGM-guided insulin titration increased inpatient time in range from 62.7% to 77.6% versus point-of-care glucose testing.
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Structured PICO summaries for doctors and healthcare professionals, covering population, intervention, comparison, outcomes, expert commentary, and references across diabetes, endocrinology, obesity, and cardiometabolic medicine.
In a phase 3 noninferiority trial, an AI-led Diabetes Prevention Program was noninferior to human coaching for a 12-month composite of weight, physical activity and HbA1c outcomes.
In a 40-week phase 3 trial in China, tirzepatide 10 mg or 15 mg added to basal insulin reduced HbA1c more than placebo, with mainly mild or moderate gastrointestinal events.
A randomized crossover clamp study found that hypoglycemia prolonged QTc, with recovery by 90 minutes after euglycemia and no effect from mineralocorticoid receptor blockade.
A 12-week sleep intervention did not improve HbA1c, CGM metrics or objective sleep versus attention control in adults with type 1 diabetes; a lower HbA1c appeared only with baseline HbA1c of 7% or above.
In the 3-year PRISM trial (n=884), a precision-medicine programme doubled attainment of three or more treatment targets but did not reduce diabetes complications in Chinese adults with young-onset diabetes.
In the prespecified VESALIUS-CV diabetes subgroup (n=3655), evolocumab lowered LDL-C to 52 vs 111 mg/dL and reduced first major cardiovascular events (HR 0.69; 95% CI 0.52 to 0.91).
In a 25-person crossover trial, ultra-rapid lispro blunted the glucose fall during exercise after basal rate reduction compared with lispro in adults with type 1 diabetes on conventional pump therapy.
In HISTORI (n=154), semaglutide 1.0 mg weekly for 30 weeks lowered fasting glucose by 0.87 mmol/L and improved insulin sensitivity in people with schizophrenia, prediabetes and obesity on antipsychotics.
In a multinational RCT (n=293), the virtual Diabetes Body Project improved eating disorder symptoms (d -0.30), diabetes distress and body image versus education control; effects were measured only 1 to 2 weeks after.