Structured PICO summaries for doctors and healthcare professionals, covering population, intervention, comparison, outcomes, expert commentary, and references across diabetes, endocrinology, obesity, and cardiometabolic medicine.
A process evaluation within the PROGROUP feasibility trial finds a 4-day training programme prepares clinicians to deliver group obesity care with moderate fidelity, and was revised toward flexible self-directed learning. PICO summary and commentary.
A 12-week RCT finds gallic acid plus exercise modestly reduces waist circumference, waist-hip ratio, and skinfolds in obesity, with benefits concentrated in the exercise-plus-supplement combination. PICO summary and commentary.
An RCT finds pentoxifylline reduces microalbuminuria, preserves eGFR, and improves left ventricular mass index over 12 months in advanced diabetic nephropathy, using surrogate endpoints. PICO summary and commentary.
A sham-controlled, blinded RCT finds electroacupuncture modestly reduces BMI and improves metabolic markers and quality of life in obese PCOS, sustained to 24 weeks. PICO summary and commentary.
An open RCT finds a smart-speaker virtual assistant with a behavioural intervention reduces mental distress and improves quality of life, self-care, and HbA1c in older adults with type 2 diabetes. PICO summary and commentary.
A small exploratory study finds combining empagliflozin with linagliptin shifts urinary microbiota toward a healthy pattern in type 2 diabetes, while empagliflozin alone raises some uropathogens; infection rates were not measured. PICO summary and commentary.
An RCT finds ILM peeling during vitrectomy for proliferative diabetic retinopathy reduces epiretinal membrane formation and repeat anti-VEGF injections, but does not improve visual acuity. PICO summary and commentary.
A GRADE substudy finds adults adding a second drug to metformin maintain high medication adherence over 3 years with small between-drug differences, while lower adherence robustly predicts worse glycaemic control. PICO summary and commentary.
A secondary analysis of the LeIKD trial finds longer endurance-exercise duration, more than intensity, improves fitness in older patients with coronary heart disease and type 2 diabetes, with early engagement predicting adherence. PICO summary and commentary.
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