Which Has Greater Impact on Metabolism: Low Carb or Low Energy in Elite Athletes?
A metabolomics study finds low-carb high-fat diets perturb lipid metabolites more than energy restriction in elite athletes. PICO summary and expert commentary.
PICO
Structured summariesStructured PICO summaries for doctors and healthcare professionals, covering population, intervention, comparison, outcomes, expert commentary, and references across diabetes, endocrinology, obesity, and cardiometabolic medicine.
Can CKDB-322 Help Reduce Body Fat in Overweight Adults?
A 12-week double-blind RCT finds a probiotic-microalgae supplement (CKDB-322) reduces body fat, abdominal fat, triglycerides, and leptin in overweight adults; the study was manufacturer-conducted. PICO summary and commentary.
Which Diet Best Boosts Metabolism and Orexin-A in Obesity?
A small 12-month RCT finds a ketogenic diet gives the largest sustained metabolic improvements while 16:8 time-restricted eating most consistently raises orexin-A; the orexin-A findings are exploratory. PICO summary and commentary.
Do Dietary Habits Predict Weight Regain or Maintenance After Weight Loss?
A secondary analysis of Look AHEAD finds adults who regained weight showed greater declines in diet quality over 3 years than maintainers, an associational finding emphasising sustained dietary quality. PICO summary and commentary.
Does a Ketogenic Diet Change Amino Acid Metabolism in Overweight Women?
An 8-week RCT finds a ketogenic diet alters amino acid metabolism in women with overweight, raising branched-chain and α-aminobutyric acids; these are mechanistic biomarker changes, not clinical outcomes. PICO summary and commentary.
Can an Anti-Inflammatory Diet Improve Gut Health in Older Adults with Metabolic Syndrome?
An observational analysis nested in PREDIMED-Plus finds older adults with lower dietary inflammatory potential show greater gut microbiota diversity and distinct profiles, an associational finding. PICO summary and commentary.
Can Ashwagandha Help Reduce Stress and Support Weight Loss?
A 24-week RCT reports ashwagandha root extract reduces weight, BMI, stress, and food cravings versus placebo; the large weight-loss magnitude for an adaptogen supplement warrants cautious interpretation. PICO summary and commentary.
By-Band-Sleeve Trial: Gastric Bypass vs Band vs Sleeve for Severe Obesity
The large UK By-Band-Sleeve RCT finds gastric bypass and sleeve gastrectomy outperform gastric banding for weight loss and quality of life at 3 years, with bypass giving greater weight loss than sleeve and best cost-effectiveness. PICO summary and commentary.
Can Plant Extracts from D. glomerata and C. quadrangularis Help with Weight Loss and Metabolism?
A 16-week RCT reports two botanical extracts raise GLP-1 and reduce weight comparably to semaglutide, but manufacturer affiliation, implausibly strong correlations, and an unblinded comparator warrant strong caution. PICO summary and commentary.
Can Guided Walking and Plant-Based Diet Improve Weight and Body Fat?
A small 8-week RCT finds substrate-guided moderate-intensity intermittent walking plus a plant-based diet gives the largest body-fat and fitness improvements in sedentary women; effect sizes should be read cautiously. PICO summary and commentary.