A clamp-based RCT finds metformin does not reduce hepatic insulin resistance in type 1 diabetes, arguing against its use as an insulin-sensitiser. PICO summary and commentary.
Browsing: PICO
Structured PICO summaries for doctors and healthcare professionals, covering population, intervention, comparison, outcomes, expert commentary, and references across diabetes, endocrinology, obesity, and cardiometabolic medicine.
A secondary analysis finds beetroot supplements improve fatty acid and oxidant markers in coronary artery disease, but only short-term surrogates. PICO summary and commentary.
An RCT finds exogenous ketone salts produce no body-composition advantage over placebo on a hypocaloric diet. PICO summary and expert commentary.
A sham-controlled trial finds tibial nerve neurodynamic techniques improve neuropathy severity and quality of life in diabetic neuropathy, without changing nerve conduction. PICO summary and commentary.
The FINE-ONE NEJM trial finds finerenone reduces albuminuria in type 1 diabetes and CKD, a surrogate-based extension of its type 2 benefits. PICO summary and commentary.
A health-economic evaluation finds a school-based app obesity-prevention programme cost-effective in Chinese primary schools. PICO summary and expert commentary.
A small crossover trial finds a BCAA, HMB, and zinc supplement increases muscle mass and lowers inflammation in dialysis patients, but not physical performance. PICO summary and commentary.
The large D-Health trial finds monthly vitamin D does not prevent hypertension, high cholesterol, or type 2 diabetes in replete older adults. PICO summary and expert commentary.
A randomised trial finds parathyroid ischaemic preconditioning does not reduce hypoparathyroidism after thyroidectomy, with only an exploratory recovery signal. PICO summary and commentary.
A three-arm trial finds a non-diet, person-centred approach matches a hypocaloric diet on metabolic measures while improving mental well-being in women with obesity. PICO summary and commentary.