Who Was Less Likely to Join a Diabetes Exercise Trial?
A recruitment analysis finds men, Hispanics, and Spanish speakers underenrol at every step of a diabetes exercise trial despite active outreach. PICO summary and commentary.
Metabolism
Obesity and weight management, metabolic syndrome and insulin resistance, MASLD/fatty liver, and nutrition and lifestyle evidence.
Can Moxibustion Improve Memory and Insulin Resistance in Type 2 Diabetes?
A small unblinded trial finds Huayu Tongluo moxibustion improves cognition and insulin resistance in type 2 diabetes, with high placebo potential. PICO summary and commentary.
Does Metformin Improve Insulin Resistance in Type 1 Diabetes?
A clamp-based RCT finds metformin does not reduce hepatic insulin resistance in type 1 diabetes, arguing against its use as an insulin-sensitiser. PICO summary and commentary.
Can Beetroot Supplements Improve Heart Health in CAD Patients?
A secondary analysis finds beetroot supplements improve fatty acid and oxidant markers in coronary artery disease, but only short-term surrogates. PICO summary and commentary.
Can Exogenous Ketones Improve Fat Loss and Preserve Muscle on a Low-Calorie Diet?
An RCT finds exogenous ketone salts produce no body-composition advantage over placebo on a hypocaloric diet. PICO summary and expert commentary.
Is a School-Based App Intervention Cost-Effective for Reducing Childhood Obesity in China?
A health-economic evaluation finds a school-based app obesity-prevention programme cost-effective in Chinese primary schools. PICO summary and expert commentary.
Can HMB and BCAAs Help Prevent Muscle Loss in Dialysis Patients?
A small crossover trial finds a BCAA, HMB, and zinc supplement increases muscle mass and lowers inflammation in dialysis patients, but not physical performance. PICO summary and commentary.
Does Monthly Vitamin D Supplementation Prevent Heart and Metabolic Diseases in Older Adults?
The large D-Health trial finds monthly vitamin D does not prevent hypertension, high cholesterol, or type 2 diabetes in replete older adults. PICO summary and expert commentary.
Can a Non-Diet Approach Improve Health and Mental Well-Being in Women with Obesity?
A three-arm trial finds a non-diet, person-centred approach matches a hypocaloric diet on metabolic measures while improving mental well-being in women with obesity. PICO summary and commentary.
Can Exercise and Fisetin Improve Inflammation and Fat Hormones in Obese Men?
A four-arm trial finds combined training plus fisetin most improves adipokines and lipids in men with obesity, with exercise the main driver. PICO summary and commentary.