Browsing: Metabolism

Clinical Context Bariatric surgery produces dramatic weight loss and metabolic improvement, but outcomes vary substantially between patients. Understanding what predicts…

A within-trial analysis of the PROLIFIC RCT finds a family-based lifestyle programme cost-effective for cardiovascular risk reduction in relatives of premature CHD patients. PICO summary and commentary.

An RCT finds curcumin lowers blood pressure, LDL, and inflammatory markers in type 2 diabetes but does not change HbA1c or glucose. PICO summary and expert commentary.

A 50-year follow-up of the Auckland Steroid Trial finds no transgenerational metabolic harm in the grandchildren of antenatal-steroid pregnancies. PICO summary and commentary.

A secondary analysis of a 12-month randomised trial found that 4:3 intermittent fasting improved binge and uncontrolled eating versus daily calorie restriction, with no difference in appetite hormones. PICO summary and expert commentary.

A multicentre randomised controlled trial tested whether a cognitive behavioural therapy-based digital dietary programme improved glycaemic control and pregnancy outcomes in gestational diabetes. PICO summary and expert commentary.

A preschool trial finds body composition improved over time with game-based activity, but moderate-to-vigorous activity did not significantly beat light activity. PICO summary and commentary.

A 6-month school-based MyBFF@school program improved fasting insulin, HOMA-IR, and HDL-C versus standard schooling in overweight Malaysian children, though BMI still rose. PICO summary and expert commentary.

A triple-blind RCT finds cinnamon supplementation does not significantly reduce weight or BMI in type 2 diabetes. PICO summary and expert commentary.

A single-centre Egyptian RCT testing whether adding Islamic intermittent fasting to lifestyle modification improves metabolic syndrome markers, with PICO summary and expert commentary.