The ARIADNE non-inferiority trial tested whether a supported total diet replacement programme worsened eating disorder symptoms in adults with type 2 diabetes at high risk. PICO summary and expert commentary.
Browsing: Metabolism
Obesity and weight management, metabolic syndrome and insulin resistance, MASLD/fatty liver, and nutrition and lifestyle evidence.
A double-blind RCT testing whether the Omentin-1 Val109Asp genotype modifies vitamin D’s effects on HDL-C, insulin resistance and abdominal obesity in prediabetic women. PICO summary and expert commentary.
A SURMOUNT-2 subpopulation analysis of 41 Japanese adults with type 2 diabetes and obesity, in which once-weekly tirzepatide produced significant 72-week weight loss versus placebo, tempered by a very small sample. PICO summary and expert commentary.
A LIFE-Moms secondary analysis finds maternal metabolic phenotype drives gestational diabetes and infant adiposity beyond weight gain, with similar treatment response. PICO summary and commentary.
A randomised trial finds a self-management programme improves social quality-of-life domains, but not general health, in obese patients awaiting joint replacement. PICO summary and commentary.
A prediction-model study finds a nomogram of preoperative HDL-C and visceral fat forecasts visceral fat loss after sleeve gastrectomy (AUC 0.88). PICO summary and commentary.
Clinical Context First-degree relatives of individuals with premature coronary heart disease (CHD before age 55 in men, 65 in women)…
An RCT finds reducing sitting did not help metabolic flexibility overall, but those cutting at least 30 minutes a day of sitting improved it. PICO summary and commentary.
A dose-comparison follow-up finds prenatal DHA 800 mg/day improves infant visual learning over 200 mg/day, though effects are domain-specific. PICO summary and commentary.
Clinical Context Sedentary behavior—prolonged sitting or reclining with minimal energy expenditure—has emerged as an independent risk factor for cardiometabolic disease,…