A small open-label RCT found no significant difference in clinical pregnancy rates between letrozole ovulation and programmed endometrial preparation for frozen embryo transfer in women with PCOS, with letrozole needing simpler luteal support. PICO summary and expert commentary.
Browsing: Reproductive Endocrinology
PCOS, hypogonadism, fertility, menopause, and hormone therapy.
Summary: In patients with diabetic erectile dysfunction (ED), high-activity placenta-derived mesenchymal stem cells (hPMSCs) combined with low-intensity extracorporeal shock wave…
A small single-centre RCT of CGM-guided individualised care versus self-monitoring in 80 women with diabetes in pregnancy, with no between-group glycaemic superiority demonstrated. PICO summary and expert commentary.
A manufacturer-sponsored randomized trial of a low-glycemic-index/slow-digesting carbohydrate product in obese pregnant women found no effect on the primary glycemic outcomes. PICO summary and expert commentary.
A three-arm RCT finds moxibustion plus low-dose tadalafil outperforms either alone for diabetic erectile dysfunction, in an unblinded single-centre setting. PICO summary and commentary.
An RCT finds Wuziyuye Decoction improves sperm motility and concentration over L-carnitine in diabetic men, but without improving pregnancy rates. PICO summary and commentary.
Clinical Context Type 2 diabetes affects male fertility through multiple interconnected mechanisms. Chronic hyperglycemia generates oxidative stress that damages sperm…
Clinical Context Erectile dysfunction (ED) affects 35-75% of men with diabetes mellitus, with prevalence increasing with diabetes duration, poor glycemic…
An RCT finds adding semaglutide to metformin improves weight, testosterone, and natural pregnancy rates in women with PCOS. PICO summary and expert commentary.
An open-label multicentre RCT in 155 women with PCOS found that a letrozole ovulation regimen for frozen-thawed embryo transfer achieved clinical pregnancy rates comparable to a programmed regimen while requiring simpler luteal support. PICO summary and expert commentary.