A crossover RCT finds weekly structured telehealth modestly lowers HbA1c and improves time in range in poorly controlled paediatric type 1 diabetes, without more hypoglycaemia. PICO summary and commentary.
Browsing: Type 1 Diabetes
Clinical Context Pediatric type 1 diabetes management is notoriously difficult, with most children and adolescents failing to achieve glycemic targets.…
Summary: In adults with type 1 diabetes and suboptimal glycemic control (HbA1c ≥ 7.5%), a Bayesian decision support system (DSS)…
A 12-month study finds adolescents with poorly controlled type 1 diabetes have low bone density, but glycaemic change does not correlate with bone, while IGF-1 does. PICO summary and commentary.
A placebo-controlled RCT finds metformin does not cut total insulin in type 1 diabetes pregnancy, but reduces mealtime insulin and weight gain in insulin-resistant women. PICO summary and commentary.
Summary: In 126 pregnant women with type 1 diabetes, metformin (titrated to 1000 mg twice daily) as adjunct to standard…
A qualitative realist evaluation finds a text-message programme supports type 1 diabetes care transition mainly via knowledge and motivation, with effects varying by individual. PICO summary and commentary.
A phase 2a crossover trial finds the GPR119 agonist MBX-2982 does not improve glucagon counterregulation in type 1 diabetes, despite target engagement. PICO summary and commentary.
A post hoc analysis of the ADJUNCT ONE and ADJUNCT TWO trials identifies who discontinues adjunctive liraglutide in type 1 diabetes: longer disease duration, undetectable C-peptide, and lower BMI. PICO summary and expert commentary.
A small randomized crossover study in eight adults with type 1 diabetes on automated insulin delivery found that splitting isomaltulose into smaller servings during exercise produced steadier plasma glucose than a single pre-exercise serving. PICO summary and expert commentary.