A small crossover study finds a high-carb diet shifts exercise fuel toward carbohydrate, while low-carb diets give more time in euglycaemia and less hyperglycaemia around fasted exercise in type 1 diabetes. PICO summary and commentary.
A 26-week double-blind RCT finds metformin does not reduce insulin resistance in adults with type 1 diabetes, with no change in endogenous glucose production versus placebo. PICO summary and commentary.
A small pilot RCT finds early automated insulin delivery is feasible and well accepted in underresourced youth with new type 1 diabetes, with a non-significant trend toward better glucose control. PICO summary and commentary.
A small RCT finds a digital-twin decision-support system with a simulation-assisted bolus calculator improves time in range and reduces hypoglycaemia in type 1 diabetes. PICO summary and commentary.
A small open-label RCT finds early NPH insulin plus infusion speeds resolution of severe DKA and delays rebound hyperglycaemia, without a significant difference in hypoglycaemia. PICO summary and commentary.
A crossover trial finds two extended-bolus algorithms both control post-meal glucose in adolescent type 1 diabetes; the simpler Sieradzki method trends better but not significantly. PICO summary and commentary.
A small pilot finds a fully closed-loop insulin-pramlintide system without carb counting achieves time in range similar to carb-counted control, with a non-significant hypoglycaemia signal. PICO summary and commentary.
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