Evidence summaries and landmark trials across type 1, type 2, prevention, glycaemic control, complications, and diabetes technology.
A 58-patient single-site implementation RCT of the community-health-worker-led TIME programme for uninsured Hispanic adults with type 2 diabetes, with PICO summary and expert commentary.
An open-label randomized trial in newly diagnosed type 2 diabetes found acarbose and vildagliptin both lowered plasma TMAO, with a greater fall on acarbose. PICO summary and expert commentary.
An MRI sub-study of the MemAID trial found that 24 weeks of intranasal insulin increased several hippocampal and medio-prefrontal resting-state connectivity measures versus placebo in 11 adults with type 2 diabetes. PICO summary and expert commentary.
A pragmatic RCT testing whether brief telehealth problem-solving therapy (LISTEN) reduces diabetes distress in adults with type 1 and type 2 diabetes versus usual web-based resources. PICO summary and expert commentary.
A 602-participant Taiwanese RCT found a single one-hour diabetes Conversation Map session modestly lowered three-month HbA1c, with the benefit mediated by diet rather than exercise. PICO summary and expert commentary.
A Peplau-theory self-care education programme improved self-reported self-care but not total treatment adherence in 102 elderly patients with diabetes. PICO summary and expert commentary.
A 92-patient randomized trial in Taiwan tested whether 6-month health coaching improves eGFR in type 2 diabetes with early-stage CKD. PICO summary and expert commentary.
An exploratory plasma proteomic analysis of the Phase 2b MOSAIC trial maps selonsertib activity to fibrosis, inflammation and oxidative-stress pathways in diabetic kidney disease, with PICO summary and expert commentary.
A prespecified FIGARO-DKD subgroup analysis of 325 Chinese adults with type 2 diabetes and CKD found a significant reduction in the secondary kidney outcome with finerenone but no significant cardiovascular benefit. PICO summary and expert commentary.
A small open-label RCT testing whether real-time CGM feedback added to individualized nutrition therapy improves diet and sleep in prediabetes with overweight or obesity. PICO summary and expert commentary.
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