Summary: In a post hoc analysis of three clinical trials spanning the glucose tolerance spectrum, fasting and 1-hour circulating Gremlin…
Browsing: Diabetes Prevention
A 4-arm randomised trial in older adults with prediabetes found HIIT improved peripheral but not whole-body insulin sensitivity, with walking showing the opposite pattern. PICO summary and expert commentary.
The ROBUST study protocol describes a planned randomized trial of a social network-enhanced lifestyle intervention for obesity in Black and Hispanic adults, with no outcome results yet. PICO summary and expert commentary.
A design, recruitment, and baseline-characteristics report for the PREDIABETEXT cluster randomised trial of a digital diabetes-prevention intervention, with no efficacy outcomes yet reported. PICO summary and expert commentary.
A 6-month structured anti-inflammatory diet-and-exercise programme in 542 adults with prediabetes delayed diabetes onset but did not lower 8-year incidence. PICO summary and expert commentary.
A small randomized trial compared perindopril plus indapamide against perindopril plus moxonidine (both with metformin) for left ventricular and renal protection in hypertension with prediabetes. PICO summary and expert commentary.
In 22,220 older US adults, daily vitamin D did not significantly reduce incident type 2 diabetes, though a pooled meta-analysis hinted at a modest benefit. PICO summary and expert commentary.
A single-centre randomised trial of 200 women found metformin matched insulin for glycaemic control in gestational diabetes, with some neonatal outcomes favouring metformin. PICO summary and expert commentary.
A Hong Kong cluster RCT found point-of-care capillary HbA1c screening doubled uptake and detected more type 2 diabetes than venous HbA1c testing in at-risk primary care patients. PICO summary and expert commentary.
A 3-month randomised controlled trial found that a 10-hour time-restricted eating window did not alter mitochondrial bioenergetics in blood cells of adults at high type 2 diabetes risk. PICO summary and expert commentary.