An exploratory plasma proteomic analysis of the Phase 2b MOSAIC trial maps selonsertib activity to fibrosis, inflammation and oxidative-stress pathways in diabetic kidney disease, with PICO summary and expert commentary.
Browsing: Diabetes Complications
Microvascular and macrovascular complications of diabetes: retinopathy, nephropathy, neuropathy, and cardiovascular risk.
A prespecified FIGARO-DKD subgroup analysis of 325 Chinese adults with type 2 diabetes and CKD found a significant reduction in the secondary kidney outcome with finerenone but no significant cardiovascular benefit. PICO summary and expert commentary.
A 96-patient randomised controlled trial of manufacturer-developed autologous platelet gel versus standard dressings for chronic neuropathic diabetic foot ulcers, with PICO summary and expert commentary.
A double-blind RCT in 67 children found Ringer’s lactate shortened time to DKA resolution versus 0.9% saline, with less hyperchloraemia. PICO summary and expert commentary.
A within-trial economic evaluation of the CIC-PDD integrated care model for type 2 diabetes with depressive symptoms reports a cost per QALY around $7,400 to $7,900. PICO summary and expert commentary.
A decentralized n-of-1 crossover trial found dapagliflozin lowered the urine albumin-to-creatinine ratio by 15.1% versus placebo over 1-week periods in 20 adults with type 2 diabetes, while demonstrating reliable remote sampling. PICO summary and expert commentary.
A secondary analysis of the EARLIER trial found that diabetes plus CKD predicted worse cardiovascular outcomes in acute heart failure, while eplerenone’s effects appeared consistent across subgroups. PICO summary and expert commentary.
An RCT finds lower-limb resistance training improves glycaemic control and quality of life in diabetic foot ulcer patients, but not wound healing. PICO summary and commentary.
A phase 2b randomized trial found that cotadutide reduced urinary albumin-to-creatinine ratio versus placebo in type 2 diabetes with chronic kidney disease, a surrogate signal requiring confirmation. PICO summary and expert commentary.
A post hoc analysis of SUSTAIN 6 reports lower odds of new-onset diabetic kidney disease with semaglutide versus placebo in people with type 2 diabetes. PICO summary and expert commentary.