Microvascular and macrovascular complications of diabetes: retinopathy, nephropathy, neuropathy, and cardiovascular risk.
A non-inferiority trial finds once-daily prolonged-release pregabalin relieves diabetic nerve pain as well as immediate-release, offering simpler dosing. PICO summary and commentary.
A small RCT finds hyaluronic acid adds no periodontal benefit over mechanical cleaning in diabetic periodontitis, though HbA1c fell only in the HA group. PICO summary and commentary.
A double-blind RCT finds wound-blotting-guided biofilm management improves the DMIST wound score and biofilm removal in diabetic foot ulcers. PICO summary and commentary.
A small three-arm trial finds stem cells plus shock wave therapy outperform either alone for diabetic erectile dysfunction, a proof-of-concept result. PICO summary and commentary.
A published BMJ Open study protocol for a planned randomised controlled trial of a COM-B-based exercise intervention in prefrail older adults with diabetes; no efficacy results are reported. PICO summary and expert commentary.
A proof-of-concept cluster randomised trial found the INTEGRATE-D implementation support intervention feasible and acceptable in primary care, with mixed effects on process and clinical outcomes. PICO summary and expert commentary.
A published protocol for the D-REM pragmatic randomized trial testing community paramedic home visits versus usual care in adults with diabetes and level 3 hypoglycemia. No outcomes are reported yet. PICO summary and expert commentary.
A secondary analysis of the FINGER lifestyle trial found that baseline dysglycaemia, especially OGTT-derived measures, was associated with less favourable cognitive and brain changes, while HbA1c showed mixed results. PICO summary and expert commentary.
An MRI sub-study of the MemAID trial found that 24 weeks of intranasal insulin increased several hippocampal and medio-prefrontal resting-state connectivity measures versus placebo in 11 adults with type 2 diabetes. PICO summary and expert commentary.
A 92-patient randomized trial in Taiwan tested whether 6-month health coaching improves eGFR in type 2 diabetes with early-stage CKD. PICO summary and expert commentary.
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