Diabetes Complications
Microvascular and macrovascular complications of diabetes: retinopathy, nephropathy, neuropathy, and cardiovascular risk.
Does Biofilm-Guided Wound Care Improve Diabetic Foot Ulcers?
A double-blinded RCT in 162 adults found wound blotting-guided biofilm management improved the DMIST wound score and biofilm removal over three weeks in diabetic foot ulcers, though only surrogate endpoints were measured. PICO summary and expert commentary.
What Factors Affect DME Resolution After Dexamethasone Treatment?
A MEAD post-hoc analysis finds the dexamethasone implant doubles diabetic macular oedema resolution, with thicker baseline maculae resolving more slowly. PICO summary and commentary.
Urinary EGF and Uromodulin and Diabetic Kidney Disease Progression
A secondary analysis of the VA NEPHRON-D cohort found that higher baseline urinary EGF and uromodulin were independently associated with a lower risk of diabetic kidney disease progression. PICO summary and expert commentary.
Previsit Activation and Diabetes Deprescribing in Older Adults
A randomized trial testing whether a patient previsit activation handout, added to physician academic detailing, increases diabetes medication deprescribing in adults 75 and older. PICO summary and expert commentary.
Do Ketone Bodies Affect the Heart Differently in Type 1 Diabetes?
A randomized crossover trial found the cardiac output response to 3-hydroxybutyrate was blunted by roughly 80% in type 1 diabetes, with no gain in systolic function and reduced ventricular work efficiency. PICO summary and expert commentary.
N-Acetyl-Cysteine as Adjuvant Therapy Accelerates Response in Diabetic Foot Osteomyelitis: Open-Label RCT
An open-label RCT finds N-acetylcysteine speeds the fall in inflammatory markers in diabetic foot osteomyelitis, though clinical outcomes were not measured. PICO summary and commentary.
Can Statins Help Treat Diabetic Macular Edema?
A small RCT suggests low-dose atorvastatin may aid anti-VEGF therapy for diabetic macular edema more than high-dose, though key endpoints were non-significant. PICO summary and commentary.
Is Aflibercept Alone or Combined with Dexamethasone Better for Diabetic Macular Edema?
A small phase 2 trial finds adding dexamethasone to aflibercept improves diabetic macular edema outcomes with no IOP rise. PICO summary and expert commentary.