A randomized crossover trial found the cardiac output response to 3-hydroxybutyrate was blunted by roughly 80% in type 1 diabetes, with no gain in systolic function and reduced ventricular work efficiency. PICO summary and expert commentary.
Browsing: Cardiovascular
Cardiovascular outcomes, heart failure, cardio-renal protection, hypertension, and lipid-lowering trials in diabetes and endocrinology.
A post-hoc EXSCEL analysis testing whether baseline ejection fraction modifies the effect of once-weekly exenatide on heart failure hospitalisation in type 2 diabetes. PICO summary and expert commentary.
Exploratory analysis of AMPLITUDE-O finds baseline FIB-4 score is not associated with cardiovascular outcomes and does not modify efpeglenatide’s effect in high-risk type 2 diabetes. PICO summary and expert commentary.
A double-blind RCT testing whether the Omentin-1 Val109Asp genotype modifies vitamin D’s effects on HDL-C, insulin resistance and abdominal obesity in prediabetic women. PICO summary and expert commentary.
A prediction-model study finds a nomogram of preoperative HDL-C and visceral fat forecasts visceral fat loss after sleeve gastrectomy (AUC 0.88). PICO summary and commentary.
Clinical Context First-degree relatives of individuals with premature coronary heart disease (CHD before age 55 in men, 65 in women)…
Clinical Context Bariatric surgery produces dramatic weight loss and metabolic improvement, but outcomes vary substantially between patients. Understanding what predicts…
A within-trial analysis of the PROLIFIC RCT finds a family-based lifestyle programme cost-effective for cardiovascular risk reduction in relatives of premature CHD patients. PICO summary and commentary.
An RCT finds curcumin lowers blood pressure, LDL, and inflammatory markers in type 2 diabetes but does not change HbA1c or glucose. PICO summary and expert commentary.
In the SOGALDI-PEF crossover trial, adding spironolactone to dapagliflozin produced a modest 11% NT-proBNP reduction in HFmrEF/HFpEF, offset by eGFR decline and higher potassium. PICO summary and expert commentary.