Do SGLT2 Inhibitors Reduce Heart Fibrosis in Diabetic HFpEF?
A randomised trial finds dapagliflozin reduces myocardial fibrosis and improves cardiac structure in diabetic HFpEF. PICO summary and expert commentary.
Cardiovascular
Cardiovascular outcomes, heart failure, cardio-renal protection, hypertension, and lipid-lowering trials in diabetes and endocrinology.
Does Weekly Exenatide Improve Heart Health by Changing Risk Factors?
An EXSCEL mediation analysis finds conventional risk-factor changes explain only part of exenatide's cardiovascular benefit and do not mediate its mortality effect. PICO summary and commentary.
Orforglipron and Cardiovascular Risk Biomarkers in Type 2 Diabetes or Obesity: An Exploratory Phase 2 Analysis
An exploratory analysis of two Phase 2 trials found that oral orforglipron produced placebo-adjusted reductions in cardiovascular risk biomarkers, not clinical events, in adults with type 2 diabetes or obesity. PICO summary and expert commentary.
Does Exenatide Help After Heart Surgery?
A large RCT finds peri-operative exenatide does not reduce death or organ failure after CABG or aortic valve replacement. PICO summary and expert commentary.
Does SGLT2 Inhibitor Use Modify Oral Semaglutide’s Cardiovascular Benefit in Type 2 Diabetes?
A prespecified SOUL trial analysis tested whether baseline SGLT2 inhibitor use modified oral semaglutide's cardiovascular benefit in type 2 diabetes. PICO summary and expert commentary.
Do Mixed Nuts Improve Cholesterol in Older Overweight Adults?
A randomised crossover trial found 60 g/day of mixed nuts for 16 weeks lowered apolipoprotein B and VLDL and LDL particle numbers in older adults with overweight or obesity. PICO summary and expert commentary.
Tafolecimab in Chinese Patients With Type 2 Diabetes and Hypercholesterolemia: A Post-Hoc Pooled Phase 3 Analysis
A post-hoc pooled analysis of three phase 3 trials testing tafolecimab 450 mg every four weeks for LDL-C lowering in Chinese adults with type 2 diabetes and hypercholesterolemia. PICO summary and expert commentary.
Acute Exenatide-Glucagon Co-Infusion and Myocardial Glucose Uptake in Type 2 Diabetes (n=8)
A small acute mechanistic crossover study testing whether exenatide-glucagon co-infusion raises myocardial glucose uptake and a diastolic strain-rate marker in eight adults with type 2 diabetes. PICO summary and expert commentary.
Does Metformin Affect Blood Pressure and Digestion After Meals in Type 2 Diabetes?
A double-blind placebo-controlled crossover study finds metformin attenuates the postprandial blood pressure fall and reduces postprandial hypotension events in type 2 diabetes, alongside higher GLP-1, slower gastric emptying, and a faster heart rate. PICO summary and expert commentary.