Browsing: Cardiovascular

A secondary analysis of the VA NEPHRON-D cohort found that higher baseline urinary EGF and uromodulin were independently associated with a lower risk of diabetic kidney disease progression. PICO summary and expert commentary.

A FOURIER subgroup analysis of 197 participants asks whether evolocumab cuts cardiovascular events in type 1 diabetes with established ASCVD. PICO summary and expert commentary.

A prespecified STRIDE subgroup analysis examined whether once-weekly semaglutide 1.0 mg improves walking distance consistently across diabetes characteristics in 792 adults with symptomatic PAD and type 2 diabetes. PICO summary and expert commentary.

A randomized crossover trial found the cardiac output response to 3-hydroxybutyrate was blunted by roughly 80% in type 1 diabetes, with no gain in systolic function and reduced ventricular work efficiency. PICO summary and expert commentary.

A post-hoc EXSCEL analysis testing whether baseline ejection fraction modifies the effect of once-weekly exenatide on heart failure hospitalisation in type 2 diabetes. PICO summary and expert commentary.

Exploratory analysis of AMPLITUDE-O finds baseline FIB-4 score is not associated with cardiovascular outcomes and does not modify efpeglenatide’s effect in high-risk type 2 diabetes. PICO summary and expert commentary.

A double-blind RCT testing whether the Omentin-1 Val109Asp genotype modifies vitamin D’s effects on HDL-C, insulin resistance and abdominal obesity in prediabetic women. PICO summary and expert commentary.

A prediction-model study finds a nomogram of preoperative HDL-C and visceral fat forecasts visceral fat loss after sleeve gastrectomy (AUC 0.88). PICO summary and commentary.

Clinical Context First-degree relatives of individuals with premature coronary heart disease (CHD before age 55 in men, 65 in women)…

Clinical Context Bariatric surgery produces dramatic weight loss and metabolic improvement, but outcomes vary substantially between patients. Understanding what predicts…