Hormone Insight Editorial Team
Clinical archive
Does time-restricted eating affect mitochondrial bioenergetics in people at high diabetes risk?
A 3-month randomised controlled trial found that a 10-hour time-restricted eating window did not alter mitochondrial bioenergetics in blood cells of adults at high type 2 diabetes risk. PICO summary and expert commentary.
Levothyroxine vs LT4-LT3 After Thyroidectomy: A Feasibility Trial
A 24-week double-blind feasibility trial (n=12) found LT4 monotherapy did not normalize free T4 and total T3 after thyroidectomy while LT4-LT3 did, but weight and cholesterol differences were non-significant. PICO summary and expert commentary.
Dapagliflozin and Individual Albuminuria Responses in Type 2 Diabetes: An N-of-1 Crossover Trial
A decentralized n-of-1 crossover trial found dapagliflozin lowered the urine albumin-to-creatinine ratio by 15.1% versus placebo over 1-week periods in 20 adults with type 2 diabetes, while demonstrating reliable remote sampling. PICO summary and expert commentary.
Do Family-Based Programs Help Adults Manage Weight?
A 2-year cluster RCT in India found a family-based, health-worker-delivered programme cut adult body weight by an adjusted 2.61 kg versus enhanced usual care. PICO summary and expert commentary.
Eplerenone in Acute Heart Failure: Effect Consistent Across Diabetes and CKD (EARLIER Secondary Analysis)
A secondary analysis of the EARLIER trial found that diabetes plus CKD predicted worse cardiovascular outcomes in acute heart failure, while eplerenone's effects appeared consistent across subgroups. PICO summary and expert commentary.
Does TransCon PTH (Palopegteriparatide) Improve Outcomes in Adults With Hypoparathyroidism?
The phase 3 PaTHway trial finds TransCon PTH frees most adults with hypoparathyroidism from conventional therapy and halves urinary calcium. PICO summary and expert commentary.
Inhaled Technosphere Insulin in Type 1 Diabetes: 30-Week Durability (INHALE-3 Extension)
A single-arm extension found HbA1c was sustained over 30 weeks in adults with type 1 diabetes who switched to inhaled technosphere insulin plus degludec. PICO summary and expert commentary.
Can Inhaled Insulin Help Type 1 Diabetes?
A 13-week single-arm switch study tested inhaled technosphere insulin plus degludec against participants' own baseline in 49 adults with type 1 diabetes. PICO summary and expert commentary.
Pioglitazone/Metformin Plus Dapagliflozin Versus Basal Insulin in Type 2 Diabetes: Primary Endpoint Not Met
An open-label trial found that pioglitazone/metformin plus dapagliflozin did not beat basal insulin/metformin on its primary glycaemic endpoint, with secondary metabolic signals favouring the oral regimen. PICO summary and expert commentary.