A 30-participant pilot randomised trial of an 8-week intensive exercise protocol versus diet plus brisk walking in young adults with obesity, with PICO summary and expert commentary.
A post-hoc analysis of the SPRINT trial finds a higher triglyceride-glucose index is associated with greater cardiovascular risk in controlled hypertension, significant only under standard blood pressure treatment. PICO summary and expert commentary.
A small single-blind RCT found that a family-centered empowerment program raised illness acceptance and self-management scores at six weeks in adults with type 2 diabetes. PICO summary and expert commentary.
A one-year randomised controlled trial testing whether pharmacist-led collaborative care improves EQ-5D quality of life and HbA1c versus routine care in adults with diabetes. PICO summary and expert commentary.
A Phase 1 crossover study in healthy Korean volunteers found the enavogliflozin/gemigliptin fixed-dose combination pharmacokinetically equivalent to the separate tablets, with food not altering enavogliflozin exposure. PICO summary and expert commentary.
A 52-week open-label randomized trial found once-weekly semaglutide reduced LDL cholesterol and shifted lipoprotein subfractions toward a less atherogenic profile versus sitagliptin in obese type 2 diabetes. PICO summary and expert commentary.
A secondary lipidomic analysis of two randomized crossover feeding trials found that lowering dietary saturated fat reshaped the lipoprotein(a) lipidome while plasma Lp(a) rose. PICO summary and expert commentary.
A secondary analysis of a 6-month randomized trial found that higher baseline weight-loss self-efficacy predicted at least 5% weight loss in both diet arms, with BMI and age as arm-specific predictors. PICO summary and expert commentary.
A 12-week randomised trial in older adults with type 2 diabetes testing whether combined aerobic plus resistance exercise improves sleep and abdominal fat. PICO summary and expert commentary.
An exploratory analysis within the FLIPAN trial links larger liver-fat reductions on a Mediterranean diet to mixed environmental signals, with only higher water use surviving adjustment. PICO summary and expert commentary.
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