A J-DOIT2 secondary analysis finds prior dropout history strongly predicts future dropout from diabetes care, with very high HbA1c a further risk marker. PICO summary and commentary.
A randomised study finds pure endoscopic pituitary surgery improves goal achievement and pituitary function preservation versus microscopic, with similar long-term outcomes. PICO summary and commentary.
A within-trial analysis of the PROLIFIC RCT finds a family-based lifestyle programme cost-effective for cardiovascular risk reduction in relatives of premature CHD patients. PICO summary and commentary.
An RCT finds curcumin lowers blood pressure, LDL, and inflammatory markers in type 2 diabetes but does not change HbA1c or glucose. PICO summary and expert commentary.
An open-label RCT finds N-acetylcysteine speeds the fall in inflammatory markers in diabetic foot osteomyelitis, though clinical outcomes were not measured. PICO summary and commentary.
A 50-year follow-up of the Auckland Steroid Trial finds no transgenerational metabolic harm in the grandchildren of antenatal-steroid pregnancies. PICO summary and commentary.
An RCT finds prophylactic antibiotics give no benefit after simple tooth extraction in well-controlled type 2 diabetes. PICO summary and expert commentary.
A small randomized three-arm trial comparing empagliflozin, sitagliptin, and metformin on glycemic and cardio-metabolic parameters in type 2 diabetes, with significance shown mainly against the metformin arm. PICO summary and expert commentary.
A secondary analysis of a 12-month randomised trial found that 4:3 intermittent fasting improved binge and uncontrolled eating versus daily calorie restriction, with no difference in appetite hormones. PICO summary and expert commentary.
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