Hormone Insight Editorial Team
Clinical archive
Does Prenatal Exercise Affect Maternal Blood Lactate?
A secondary analysis finds prenatal exercise blunts the gestational rise in resting maternal lactate, most in women with overweight or obesity. PICO summary and expert commentary.
Do SGLT2 Inhibitors Reduce Myocardial Fibrosis in Diabetic HFpEF?
A double-blind randomised trial of dapagliflozin versus placebo for myocardial fibrosis on cardiac MRI in 100 patients with type 2 diabetes and HFpEF. PICO summary and expert commentary.
Exenatide Plus Glucagon Co-Infusion Increases Myocardial Glucose Uptake and Improves Diastolic Function in Type 2 Diabetes
A small mechanistic study finds exenatide plus glucagon doubles myocardial glucose uptake in type 2 diabetes, a proof-of-concept for cardiac metabolic effects. PICO summary and commentary.
Ebenatide (PEGylated Exenatide) Improves Glycemic Control, Time in Range, and Body Composition in Type 2 Diabetes
An RCT finds the GLP-1 analogue Ebenatide improves glycaemia, time in range, and body composition in type 2 diabetes, confirming a class effect. PICO summary and commentary.
Does Personalized Care and Glucose Monitoring Improve Diabetes in Pregnancy?
A small single-centre RCT testing CGM-guided individualised care versus self-monitored blood glucose in 80 pregnant women with diabetes. PICO summary and expert commentary.
Does Acute Exenatide-Glucagon Co-Infusion Raise Myocardial Glucose Uptake in Type 2 Diabetes?
An acute crossover infusion study (n=8) found exenatide-glucagon co-infusion raised myocardial glucose uptake and a diastolic strain rate marker in type 2 diabetes. PICO summary and expert commentary.
Pharmacist-Led Care and Quality of Life in Diabetes: An Open-Label RCT
An open-label randomised trial testing pharmacist-led collaborative care against usual care on EQ-5D quality of life and HbA1c in 400 patients with diabetes. PICO summary and expert commentary.
Family-Centered Empowerment Improves Acceptance and Self-Management Scores in Type 2 Diabetes (Small RCT)
A small single-blind RCT (n=60) found a family-centered empowerment program raised diabetes acceptance and self-management questionnaire scores versus usual care, with no glycaemic outcomes measured. PICO summary and expert commentary.
Pilot RCT: Does an Integrated Intensive Exercise Protocol Improve Function in Adults with Obesity?
A small pilot randomised trial (n=30) testing whether an 8-week integrated intensive exercise protocol improves body composition, functional capacity and quality of life in young adults with obesity versus diet plus brisk walking. PICO summary and expert commentary.