A small IVUS study finds statin plus PCSK9 inhibitor drives greater plaque regression than either alone in borderline coronary lesions. PICO summary and expert commentary.
A small RCT suggests low-dose atorvastatin may aid anti-VEGF therapy for diabetic macular edema more than high-dose, though key endpoints were non-significant. PICO summary and commentary.
A small phase 2 trial finds adding dexamethasone to aflibercept improves diabetic macular edema outcomes with no IOP rise. PICO summary and expert commentary.
A 6-month school-based MyBFF@school program improved fasting insulin, HOMA-IR, and HDL-C versus standard schooling in overweight Malaysian children, though BMI still rose. PICO summary and expert commentary.
A randomised comparison finds gadobutrol non-inferior to meglumine gadoterate for pituitary DCE-MRI but with a higher Kep to recognise, not a clear superiority. PICO summary and commentary.
A post-hoc ACCORD-BP analysis links intensive blood pressure control to lower cardiovascular events in diabetics with prior stroke, without raising recurrent stroke. PICO summary and commentary.
An RCT finds the Diabetes Conversation Map improves knowledge, self-management, and self-efficacy in type 2 diabetes, though without clinical endpoints. PICO summary and commentary.
A non-inferiority trial finds once-daily prolonged-release pregabalin relieves diabetic nerve pain as well as immediate-release, offering simpler dosing. PICO summary and commentary.
An open-label multicentre RCT in 155 women with PCOS found that a letrozole ovulation regimen for frozen-thawed embryo transfer achieved clinical pregnancy rates comparable to a programmed regimen while requiring simpler luteal support. PICO summary and expert commentary.
A triple-blind RCT finds cinnamon supplementation does not significantly reduce weight or BMI in type 2 diabetes. PICO summary and expert commentary.
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