An open-label RCT finds N-acetylcysteine speeds the fall in inflammatory markers in diabetic foot osteomyelitis, though clinical outcomes were not measured. PICO summary and commentary.
A 50-year follow-up of the Auckland Steroid Trial finds no transgenerational metabolic harm in the grandchildren of antenatal-steroid pregnancies. PICO summary and commentary.
An RCT finds prophylactic antibiotics give no benefit after simple tooth extraction in well-controlled type 2 diabetes. PICO summary and expert commentary.
A small randomized three-arm trial comparing empagliflozin, sitagliptin, and metformin on glycemic and cardio-metabolic parameters in type 2 diabetes, with significance shown mainly against the metformin arm. PICO summary and expert commentary.
A secondary analysis of a 12-month randomised trial found that 4:3 intermittent fasting improved binge and uncontrolled eating versus daily calorie restriction, with no difference in appetite hormones. PICO summary and expert commentary.
In the SOGALDI-PEF crossover trial, adding spironolactone to dapagliflozin produced a modest 11% NT-proBNP reduction in HFmrEF/HFpEF, offset by eGFR decline and higher potassium. PICO summary and expert commentary.
An RCT finds nasal mask oxygenation sharply reduces hypoxemia during sedated gastroscopy in obese and OSA patients. PICO summary and expert commentary.
A multicentre randomised controlled trial tested whether a cognitive behavioural therapy-based digital dietary programme improved glycaemic control and pregnancy outcomes in gestational diabetes. PICO summary and expert commentary.
A preschool trial finds body composition improved over time with game-based activity, but moderate-to-vigorous activity did not significantly beat light activity. PICO summary and commentary.
An RCT finds adding semaglutide to metformin improves weight, testosterone, and natural pregnancy rates in women with PCOS. PICO summary and expert commentary.
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