A small single-centre RCT of CGM-guided individualised care versus self-monitoring in 80 women with diabetes in pregnancy, with no between-group glycaemic superiority demonstrated. PICO summary and expert commentary.
A prespecified, descriptive subgroup analysis of a phase 2 survodutide trial examined how sex and baseline BMI shaped weight and waist outcomes in 387 adults with overweight or obesity. PICO summary and expert commentary.
Acute empagliflozin produced robust, comparable urinary glucose excretion in HNF1A-MODY and type 2 diabetes during a hyperglycaemic clamp. PICO summary and expert commentary.
Post-hoc STEP 6 subgroup analysis of semaglutide versus placebo in 401 Japanese and Korean adults with overweight or obesity, testing whether sex, type 2 diabetes, and other baseline factors modify weight loss. PICO summary and expert commentary.
A phase 2 substudy found retatrutide produced dose-related reductions in total body fat mass at 36 weeks versus placebo and dulaglutide in type 2 diabetes. PICO summary and expert commentary.
A randomised crossover trial found 60 g/day of mixed nuts for 16 weeks lowered apolipoprotein B and VLDL and LDL particle numbers in older adults with overweight or obesity. PICO summary and expert commentary.
A post-hoc pooled analysis of three phase 3 trials testing tafolecimab 450 mg every four weeks for LDL-C lowering in Chinese adults with type 2 diabetes and hypercholesterolemia. PICO summary and expert commentary.
A post hoc mediation analysis of the SURMOUNT-1 to -4 trials found that gastrointestinal adverse events contributed only slightly (up to 3.1%) to tirzepatide-associated weight reduction, which was similar regardless of nausea. PICO summary and expert commentary.
A small acute mechanistic crossover study testing whether exenatide-glucagon co-infusion raises myocardial glucose uptake and a diastolic strain-rate marker in eight adults with type 2 diabetes. PICO summary and expert commentary.
A 1-year randomised controlled trial of pharmacist-led collaborative care versus standard care in 400 adults with type 2 diabetes, reporting EQ-5D and visual analogue scale quality-of-life gains alongside a larger HbA1c reduction. PICO summary and expert commentary.
Welcome to Hormone Insight. Our mission is to support clinical decision-making with accessible, evidence-based insights from recent studies and trials.
© 2024-2026 Hormone Insight. All rights reserved.
