A randomized open-label pilot trial tested whether slower, flexible semaglutide titration reduces gastrointestinal dropout in type 2 diabetes versus the label regimen. PICO summary and expert commentary.
A secondary analysis of the DIAMANTE trial finds an adaptive texting intervention did not improve patient-provider communication in diabetes and depression. PICO summary and commentary.
A small open-label RCT found no significant difference in clinical pregnancy rates between letrozole ovulation and programmed endometrial preparation for frozen embryo transfer in women with PCOS, with letrozole needing simpler luteal support. PICO summary and expert commentary.
A mechanistic randomized trial found empagliflozin reduced total-body norepinephrine turnover at 1 day and 12 weeks even as hepatic glucose production rose, with the two changes inversely correlated. PICO summary and expert commentary.
A 12-week trial finds chicory-root fibre improves whole-body insulin sensitivity and lowers triglycerides in obesity, with butyrate-producing gut bacteria enriched. PICO summary and commentary.
A 54-patient randomized trial testing intermittent Islamic fasting added to lifestyle modification against lifestyle modification alone in adults with metabolic syndrome, with greater percent-change improvements in weight and metabolic markers in the fasting arm. PICO summary and expert commentary.
A small crossover trial found almond milk offered no postprandial glycaemic benefit over 2% cow milk in adults with type 2 diabetes, with the primary glucose endpoint null. PICO summary and expert commentary.
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