Hormone Insight Editorial Team
Clinical archive
Combined Aerobic and Resistance Training Best Improves Beta-Cell Function in Type 2 Diabetes
An RCT finds combined aerobic and resistance training improves modelled insulin secretion and glucose effectiveness more than either alone in men with type 2 diabetes. PICO summary and commentary.
Curcumin Supplementation Reduces Liver Fat and Inflammation in Obese Type 2 Diabetes: 12-Month RCT
A 12-month RCT finds daily curcumin reduces liver fat, stiffness, and HbA1c and improves inflammatory and antioxidant markers in obese type 2 diabetes with fatty liver. PICO summary and commentary.
Probiotic Bifidobacterium animalis Improves Glycemic Control in Type 2 Diabetes: Crossover RCT
A crossover RCT finds a specific Bifidobacterium animalis probiotic blunts the rise in glucose and insulin resistance and raises immunoglobulins in type 2 diabetes, with modest adjunctive benefit. PICO summary and commentary.
Semaglutide Outperforms Alternative Therapies in Real-World Pragmatic Trial of Type 2 Diabetes
A 2-year pragmatic open-label trial finds once-weekly semaglutide modestly outperforms physician-chosen alternatives on HbA1c targets, with a year-1 weight advantage that fades by year 2. PICO summary and commentary.
Sitagliptin Preserves Hip Bone Density in Women with Type 2 Diabetes: SLowDOWN Trial
A 52-week phase III RCT finds sitagliptin preserves hip bone density in women with type 2 diabetes, which declines on placebo, but with no effect at other sites. PICO summary and commentary.