Hormone Insight Editorial Team

How does an interdisciplinary care model with family support impact blood pressure and glucose control in patients with hypertension and diabetes?

An RCT finds an interdisciplinary care model with family empowerment improves blood pressure, glucose, and psychosocial outcomes in comorbid hypertension and diabetes. PICO summary and commentary.

“How do metformin and ezetimibe affect gene expression and health in MAFLD patients with type 2 diabetes?”

An RCT finds adding ezetimibe to metformin raises PPAR-gamma and adiponectin expression and improves insulin resistance in diabetic fatty liver disease, though endpoints are surrogate. PICO summary and commentary.

Mesenchymal Stem Cell Exosomes Accelerate Diabetic Foot Ulcer Healing: First Randomized Trial

An early RCT finds weekly Wharton's jelly stem cell-derived exosomes markedly accelerate diabetic foot ulcer healing versus standard care, though the therapy remains investigational. PICO summary and commentary.

How do fixed-dose and separate enavogliflozin/gemigliptin combinations compare on pharmacokinetics and safety, and does food affect enavogliflozin in healthy Korean volunteers?

A phase-1 crossover study in healthy Korean volunteers found a fixed-dose enavogliflozin/gemigliptin combination pharmacokinetically equivalent to the separate tablets, with food delaying only the time to peak. PICO summary and expert commentary.

“How effective is the combination of orlistat, pioglitazone, and metformin for treating obesity in type 2 diabetes patients?”

A multicentre RCT finds adding orlistat to pioglitazone and metformin improves weight, visceral fat, and insulin sensitivity in obese type 2 diabetes, but not HbA1c. PICO summary and commentary.

Intraoperative Dexmedetomidine Reduces Glucose Variability and Insulin Requirements in Diabetic CABG Patients

An RCT finds intraoperative dexmedetomidine reduces glucose variability, insulin requirements, and CRP in diabetic off-pump CABG patients, though endpoints are surrogate. PICO summary and commentary.

“Can PDA-002 Help Diabetic Foot Ulcers?”

A phase 2 RCT finds placenta-derived cell therapy (PDA-002) for diabetic foot ulcers works best at the lowest dose and in the peripheral-artery-disease subgroup, a dose- and subgroup-specific signal. PICO summary and commentary.

Weekly Telehealth Reduces HbA1c by 0.3% in Poorly Controlled Pediatric Type 1 Diabetes: RCT

A crossover RCT finds weekly structured telehealth modestly lowers HbA1c and improves time in range in poorly controlled paediatric type 1 diabetes, without more hypoglycaemia. PICO summary and commentary.

Is a decellularized placental membrane more effective than standard care for diabetic foot ulcers?

SMS-Based Digital Intervention Fails to Improve HbA1c in Prediabetes: Lessons from PREDIABETEXT

A pragmatic cluster RCT finds an SMS lifestyle intervention for prediabetes does not improve HbA1c versus usual care, illustrating that engagement does not equal efficacy. PICO summary and commentary.