Can Beetroot Supplements Improve Heart Health in CAD Patients?
A secondary analysis finds beetroot supplements improve fatty acid and oxidant markers in coronary artery disease, but only short-term surrogates. PICO summary and commentary.
Hormone Insight Editorial Team
Clinical archive
CREDENCE: Canagliflozin Reduces Kidney Failure by 30% in Type 2 Diabetes and Albuminuric Nephropathy
The CREDENCE trial demonstrated that canagliflozin reduced the composite of end-stage kidney disease, doubling of serum creatinine, or renal or cardiovascular death by 30% in patients with type 2 diabetes and albuminuric chronic kidney disease, becoming the first dedicated renal outcomes trial to demonstrate that an SGLT2 inhibitor could substantially slow the progression of diabetic nephropathy.
Can Exogenous Ketones Improve Fat Loss and Preserve Muscle on a Low-Calorie Diet?
An RCT finds exogenous ketone salts produce no body-composition advantage over placebo on a hypocaloric diet. PICO summary and expert commentary.
Can Tibial Nerve Techniques Improve Diabetic Neuropathy and Quality of Life?
A sham-controlled trial finds tibial nerve neurodynamic techniques improve neuropathy severity and quality of life in diabetic neuropathy, without changing nerve conduction. PICO summary and commentary.
DECLARE-TIMI 58: Dapagliflozin Reduces Heart Failure Hospitalisation Across a Broader Type 2 Diabetes Population
The DECLARE-TIMI 58 trial demonstrated that dapagliflozin did not reduce 3-point MACE compared with placebo but significantly reduced the composite of cardiovascular death or hospitalisation for heart failure, driven entirely by a 27% reduction in heart failure hospitalisation, in the largest and most broadly representative SGLT2 inhibitor cardiovascular outcomes trial conducted to date.
Is Finerenone Effective for Type 1 Diabetes and Chronic Kidney Disease?
The FINE-ONE NEJM trial finds finerenone reduces albuminuria in type 1 diabetes and CKD, a surrogate-based extension of its type 2 benefits. PICO summary and commentary.
Is a School-Based App Intervention Cost-Effective for Reducing Childhood Obesity in China?
A health-economic evaluation finds a school-based app obesity-prevention programme cost-effective in Chinese primary schools. PICO summary and expert commentary.
Can HMB and BCAAs Help Prevent Muscle Loss in Dialysis Patients?
A small crossover trial finds a BCAA, HMB, and zinc supplement increases muscle mass and lowers inflammation in dialysis patients, but not physical performance. PICO summary and commentary.
Does Monthly Vitamin D Supplementation Prevent Heart and Metabolic Diseases in Older Adults?
The large D-Health trial finds monthly vitamin D does not prevent hypertension, high cholesterol, or type 2 diabetes in replete older adults. PICO summary and expert commentary.
Does Ischemic Preconditioning Help Parathyroid Recovery After Thyroid Surgery?
A randomised trial finds parathyroid ischaemic preconditioning does not reduce hypoparathyroidism after thyroidectomy, with only an exploratory recovery signal. PICO summary and commentary.