Clinical Context Erectile dysfunction (ED) affects 35-75% of men with diabetes mellitus, with prevalence increasing with diabetes duration, poor glycemic…
Browsing: PICO
Clinical Context Sedentary behavior—prolonged sitting or reclining with minimal energy expenditure—has emerged as an independent risk factor for cardiometabolic disease,…
A small RCT finds a diabetes self-management app increased patients’ perceived disease threat, highlighting digital health’s psychological effects. PICO summary and commentary.
A J-DOIT2 secondary analysis finds prior dropout history strongly predicts future dropout from diabetes care, with very high HbA1c a further risk marker. PICO summary and commentary.
Clinical Context Bariatric surgery produces dramatic weight loss and metabolic improvement, but outcomes vary substantially between patients. Understanding what predicts…
A randomised study finds pure endoscopic pituitary surgery improves goal achievement and pituitary function preservation versus microscopic, with similar long-term outcomes. PICO summary and commentary.
A within-trial analysis of the PROLIFIC RCT finds a family-based lifestyle programme cost-effective for cardiovascular risk reduction in relatives of premature CHD patients. PICO summary and commentary.
An RCT finds curcumin lowers blood pressure, LDL, and inflammatory markers in type 2 diabetes but does not change HbA1c or glucose. PICO summary and expert commentary.
An open-label RCT finds N-acetylcysteine speeds the fall in inflammatory markers in diabetic foot osteomyelitis, though clinical outcomes were not measured. PICO summary and commentary.
A 50-year follow-up of the Auckland Steroid Trial finds no transgenerational metabolic harm in the grandchildren of antenatal-steroid pregnancies. PICO summary and commentary.