A LIFE-Moms secondary analysis finds maternal metabolic phenotype drives gestational diabetes and infant adiposity beyond weight gain, with similar treatment response. PICO summary and commentary.
Browsing: PICO
A randomised trial finds a self-management programme improves social quality-of-life domains, but not general health, in obese patients awaiting joint replacement. PICO summary and commentary.
Clinical Context Pituitary adenomas are the third most common intracranial tumor, affecting up to 20% of the population based on…
A prediction-model study finds a nomogram of preoperative HDL-C and visceral fat forecasts visceral fat loss after sleeve gastrectomy (AUC 0.88). PICO summary and commentary.
Clinical Context First-degree relatives of individuals with premature coronary heart disease (CHD before age 55 in men, 65 in women)…
An RCT finds reducing sitting did not help metabolic flexibility overall, but those cutting at least 30 minutes a day of sitting improved it. PICO summary and commentary.
A three-arm RCT finds moxibustion plus low-dose tadalafil outperforms either alone for diabetic erectile dysfunction, in an unblinded single-centre setting. PICO summary and commentary.
An RCT finds Wuziyuye Decoction improves sperm motility and concentration over L-carnitine in diabetic men, but without improving pregnancy rates. PICO summary and commentary.
A dose-comparison follow-up finds prenatal DHA 800 mg/day improves infant visual learning over 200 mg/day, though effects are domain-specific. PICO summary and commentary.
Clinical Context Type 2 diabetes affects male fertility through multiple interconnected mechanisms. Chronic hyperglycemia generates oxidative stress that damages sperm…