A BMJ RCT finds time-restricted eating plus exercise before and during pregnancy does not prevent gestational diabetes in high-risk people. PICO summary and commentary.
Browsing: PICO
A lipidomics analysis from the randomised EmDia trial finds empagliflozin remodels plasma lipids in type 2 diabetes, raising beneficial LPCs but also harmful ceramides. PICO summary and commentary.
A placebo-controlled RCT finds metformin does not cut total insulin in type 1 diabetes pregnancy, but reduces mealtime insulin and weight gain in insulin-resistant women. PICO summary and commentary.
Summary: In 126 pregnant women with type 1 diabetes, metformin (titrated to 1000 mg twice daily) as adjunct to standard…
An OPTION post-hoc analysis finds indobufen-based antiplatelet therapy after stenting performs consistently regardless of diabetes status, with a similar bleeding advantage. PICO summary and commentary.
A qualitative realist evaluation finds a text-message programme supports type 1 diabetes care transition mainly via knowledge and motivation, with effects varying by individual. PICO summary and commentary.
Summary: In adults with HFpEF (EF ≥50%), obesity (BMI ≥30 kg/m²), stratified by presence or absence of type 2 diabetes…
A prespecified SUMMIT analysis finds tirzepatide reduces heart-failure events in obese HFpEF regardless of diabetes status, despite less weight loss with diabetes. PICO summary and commentary.
Summary: In adults with uncontrolled type 2 diabetes in China, a mobile app-based intervention significantly improved HbA1c and systolic blood…
A multicentre RCT finds a 12-month text-message programme modestly improves HbA1c and blood pressure in poorly controlled type 2 diabetes, but not LDL. PICO summary and commentary.