A placebo-controlled RCT finds metformin does not cut total insulin in type 1 diabetes pregnancy, but reduces mealtime insulin and weight gain in insulin-resistant women. PICO summary and commentary.
Browsing: PICO
Structured PICO summaries for doctors and healthcare professionals, covering population, intervention, comparison, outcomes, expert commentary, and references across diabetes, endocrinology, obesity, and cardiometabolic medicine.
Summary: In 126 pregnant women with type 1 diabetes, metformin (titrated to 1000 mg twice daily) as adjunct to standard…
An OPTION post-hoc analysis finds indobufen-based antiplatelet therapy after stenting performs consistently regardless of diabetes status, with a similar bleeding advantage. PICO summary and commentary.
A qualitative realist evaluation finds a text-message programme supports type 1 diabetes care transition mainly via knowledge and motivation, with effects varying by individual. PICO summary and commentary.
Summary: In adults with HFpEF (EF ≥50%), obesity (BMI ≥30 kg/m²), stratified by presence or absence of type 2 diabetes…
A prespecified SUMMIT analysis finds tirzepatide reduces heart-failure events in obese HFpEF regardless of diabetes status, despite less weight loss with diabetes. PICO summary and commentary.
Summary: In adults with uncontrolled type 2 diabetes in China, a mobile app-based intervention significantly improved HbA1c and systolic blood…
A multicentre RCT finds a 12-month text-message programme modestly improves HbA1c and blood pressure in poorly controlled type 2 diabetes, but not LDL. PICO summary and commentary.
A qualitative study finds most interviewed patients describe positive experiences and symptom relief with acupuncture for diabetic neuropathy, but it cannot prove efficacy. PICO summary and commentary.
A phase-3 secondary analysis finds enavogliflozin lowers leptin independent of weight in type 2 diabetes, while the adiponectin rise was weight-dependent. PICO summary and commentary.