A 93-patient RCT found structured exercise after gastric bypass did not improve the primary 2-hour glucose endpoint but added modest weight and fat-mass loss. PICO summary and expert commentary.
Browsing: Obesity & Weight Management
Evidence summaries for obesity and weight management, including lifestyle trials, pharmacotherapy, bariatric/metabolic outcomes, cardiometabolic risk, and long-term safety.
A small randomised trial finding that weight loss reduced IL-1β and MASLD comparably with liraglutide or lifestyle, and that baseline IL-1β predicted the extent of MASLD improvement. PICO summary and expert commentary.
The NIGOHealth randomized trial found no effect of a low glycaemic index/slow digesting carbohydrate product on primary maternal glycaemia outcomes in obese pregnant women, with only a small secondary HbA1c difference. PICO summary and expert commentary.
A single-centre Chinese RCT found a mobile health lifestyle programme modestly reduced gestational weight gain and fasting glucose in overweight or obese pregnant women, with no effect on gestational diabetes incidence. PICO summary and expert commentary.
A randomised non-inferiority trial of a low-energy total diet replacement programme in people with type 2 diabetes at high eating-disorder risk: PICO summary and expert commentary.
An exploratory secondary analysis of two Phase 2 trials reports that oral orforglipron lowered blood pressure, LDL cholesterol, triglycerides, ApoB, ApoC3, and hsCRP versus placebo, though no cardiovascular events were measured. PICO summary and expert commentary.
A small single-centre randomised trial testing weight-lowering hypoglycaemic agents plus a high-protein diet and moderate exercise against standard care for diabetes remission in adults with obesity. PICO summary and expert commentary.
An exploratory randomised trial of an 880 kcal/day total diet replacement programme in 17 adults with compensated MASLD cirrhosis found safe weight loss and reduced liver fat, but cannot confirm efficacy. PICO summary and expert commentary.
The ROBUST study protocol describes a planned randomized trial of a social network-enhanced lifestyle intervention for obesity in Black and Hispanic adults, with no outcome results yet. PICO summary and expert commentary.
A small single-centre randomised trial mapped subcutaneous adipose gene-expression changes after six months of lifestyle-induced weight loss in men with metabolic syndrome. PICO summary and expert commentary.