The ROBUST study protocol describes a planned randomized trial of a social network-enhanced lifestyle intervention for obesity in Black and Hispanic adults, with no outcome results yet. PICO summary and expert commentary.
Browsing: Obesity & Weight Management
A small single-centre randomised trial mapped subcutaneous adipose gene-expression changes after six months of lifestyle-induced weight loss in men with metabolic syndrome. PICO summary and expert commentary.
Summary: In 1,145 patients with obesity-related HFpEF (LVEF ≥45%, BMI ≥30 kg/m²) from the pooled STEP-HFpEF trials, semaglutide 2.4 mg…
A randomized crossover trial in 75 young adults found acute sucralose raised hypothalamic blood flow and, versus sucrose, increased hunger, with no hunger difference versus water. PICO summary and expert commentary.
A 3-month randomised controlled trial found that a 10-hour time-restricted eating window did not alter mitochondrial bioenergetics in blood cells of adults at high type 2 diabetes risk. PICO summary and expert commentary.
A 2-year cluster RCT in India found a family-based, health-worker-delivered programme cut adult body weight by an adjusted 2.61 kg versus enhanced usual care. PICO summary and expert commentary.
A small mechanistic randomized trial found once-daily oral semaglutide 50 mg cut ad libitum energy intake by 39.2 percentage points versus placebo and reduced body weight, with no change in gastric emptying. PICO summary and expert commentary.
STEP 10 phase 3 RCT: once-weekly semaglutide 2.4 mg cut bodyweight by 13.9% and drove reversion to normoglycaemia in adults with obesity and prediabetes. PICO summary and expert commentary.
Pooled subgroup analysis of STEP-HFpEF and STEP-HFpEF-DM finds once-weekly semaglutide 2.4 mg improves symptoms and weight across diuretic strata and cuts loop diuretic dose in obesity-related HFpEF. PICO summary and expert commentary.
A prespecified pooled secondary analysis of the STEP-HFpEF trials found semaglutide improved symptoms, weight, and exercise capacity consistently across baseline C-reactive protein strata and lowered CRP regardless of weight loss. PICO summary and expert commentary.