Summary: In adults with obesity, exposure to GLP-1 receptor agonists and bariatric surgery significantly increased policy support for obesity treatments…
Browsing: Obesity & Weight Management
An oral GLP-1 receptor agonist lowered HbA1c and body weight in phase 2 but was halted early after transaminase elevations ended its development. PICO summary and expert commentary.
A 253-adult randomized trial found that 25% calorie restriction produced consistent enteropancreatic hormone shifts across diet patterns, and that larger shifts were associated with more weight regain afterwards. PICO summary and expert commentary.
A 56-week randomized, double-blind, placebo-controlled trial of liraglutide 3.0 mg for weight recurrence after Roux-en-Y gastric bypass. PICO summary and expert commentary.
A first-in-human phase I trial of the NPY2 receptor agonist BI 1820237, alone or with low-dose liraglutide, in 95 men with overweight or obesity, reporting safety, tolerability, and additive effects on gastric emptying. PICO summary and expert commentary.
A small randomized trial finds baseline IL-1β in mononuclear cells predicts the degree of MASLD improvement after weight loss in obesity with prediabetes or early type 2 diabetes. PICO summary and expert commentary.
The ARIADNE non-inferiority trial tested whether a supported total diet replacement programme worsened eating disorder symptoms in adults with type 2 diabetes at high risk. PICO summary and expert commentary.
A SURMOUNT-2 subpopulation analysis of 41 Japanese adults with type 2 diabetes and obesity, in which once-weekly tirzepatide produced significant 72-week weight loss versus placebo, tempered by a very small sample. PICO summary and expert commentary.
A randomised trial finds a self-management programme improves social quality-of-life domains, but not general health, in obese patients awaiting joint replacement. PICO summary and commentary.
A prediction-model study finds a nomogram of preoperative HDL-C and visceral fat forecasts visceral fat loss after sleeve gastrectomy (AUC 0.88). PICO summary and commentary.